Prognostic value of Sirtuin1 in acute ischemic stroke and its correlation with functional outcomes

Background: The blood-brain barrier is impaired in patients with stroke. The release of protein markers such as Sirtuin1 (SIRT1) into circulation may be useful to assess the prognosis of patients with cerebrovascular disease. In this study, we investigated the predictive value of SIRT1 levels in acute ischemic stroke (AIS) patients. Methods: In all, 101 AIS patients and 38 healthy controls were enrolled, and blood samples were collected within 72 hours of stroke onset. SIRT1 was analyzed using a commercially available enzyme-linked immunosorbent assay kit. On admission, neurological status was assessed by the standardized National Institutes of Health Stroke Scale (NIHSS). Functional outcomes were measured 1 year after admission using the modified Rankin scale. Results: Compared with the control group, SIRT1 was significantly increased in the AIS group (0.63 +/- 0.75 vs 0.48 +/- 0.80ng/mL; P <= 0.05). However, there was no significant correlation between SIRT1 and NIHSS score at admission (r=-0.01, P=.920). In addition, with an unadjusted odds ratio of 0.862 (95% confidence interval 0.495-1.502), SIRT1 was not significantly correlated with functional outcomes. Conclusions: Serum concentrations of SIRT1 have no significant predictive value for favorable functional outcome after acute stroke in our study.