Panton-Valentine Leukocidin-Positive Staphylococcus aureus Strains Are Associated with Follicular Skin Infections

被引：18

作者：

Del Giudice, Pascal ^{[1
]}

Bes, Michele ^{[2
,3
,4
]}

Hubiche, Thomas

Blanc, Veronique ^{[5
]}

Roudiere, Laurent

Lina, Gerard ^{[2
,3
,4
]}

Vandenesch, Francois ^{[2
,3
,4
]}

Etienne, Jerome ^{[2
,3
,4
]}

机构：

[1] Hop Bonnet, Unite Malad Infect & Dermatol, Serv Infectiol Dermatol, FR-83700 Frejus, France

[2] Univ Lyon 1, Ctr Natl Reference Staphylocoques, F-69365 Lyon, France

[3] INSERM, U851, IFR128, F-69008 Lyon, France

[4] Hosp Civils Lyon, Ctr Biol Est, Bron, France

[5] Ctr Hosp dAntibes Juan Les Pins, Antibes, France

来源：

DERMATOLOGY | 2011年 / 222卷 / 02期

关键词：

Staphylococcus aureus; Panton-Valentine leukocidin; Abscess; Staphylococcal skin infection; Skin infection; VIRULENCE DETERMINANT; CUTANEOUS INFECTIONS; METHICILLIN; GENES;

D O I：

10.1159/000324044

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background/Aims: Panton-Valentine leukocidin (PVL)-positive Staphylococcus aureus have been associated with suppurative infections; however, their precise role in skin infections has not been elucidated. We studied the rate of PVL-positive S. aureus in the different types of skin infections and compared follicular to nonfollicular skin infections. Methods: In our institution, patients with a skin infection caused by S. aureus were enrolled in a prospective, observational cohort study (from July 1, 2003 to June 30, 2010). We studied the rate of PVL-positive S. aureus in the different clinical types of skin infections and compared the rate of PVL-positive S. aureus in follicular infections to that in nonfollicular infections. Results: A total 229 skin infections were included: 97 (42.5%) were caused by PVL-positive strains. Thirty-nine of the 53 (74%) follicular infections [8 of the 17 (47%) with folliculitis, 30 of the 35 (85.5%) with furuncles and 1 with a carbuncle (100%)] were caused by PVL-positive S. aureus, compared to 16 of the 131 (12%) nonfollicular infections (p < 0.001). Conclusion: PVL-positive S. aureus strains are mainly associated with follicular skin infections. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：167 / 170

页数：4

共 13 条

[1] LEUKOCIDIN FROM STAPHYLOCOCCUS-AUREUS AND CUTANEOUS INFECTIONS - AN EPIDEMIOLOGIC-STUDY [J].

COUPPIE, P ;

CRIBIER, B ;

PREVOST, G ;

GROSSHANS, E ;

PIEMONT, Y .

ARCHIVES OF DERMATOLOGY, 1994, 130 (09) :1208-1209

[2] STAPHYLOCOCCUS-AUREUS LEUKOCIDIN - A NEW VIRULENCE FACTOR IN CUTANEOUS INFECTIONS - AN EPIDEMIOLOGIC AND EXPERIMENTAL-STUDY [J].

CRIBIER, B ;

PREVOST, G ;

COUPPIE, P ;

FINCKBARBANCON, V ;

GROSSHANS, E ;

PIEMONT, Y .

DERMATOLOGY, 1992, 185 (03) :175-180

[3] Primary Skin Abscesses Are Mainly Caused by Panton-Valentine Leukocidin-Positive Staphylococcus aureus Strains [J].

del Giudice, Pascal ;

Blanc, Veronique ;

de Rougemont, Alexis ;

Bes, Michele ;

Lina, Gerard ;

Hubiche, Thomas ;

Roudiere, Laurent ;

Vandenesch, Francois ;

Etienne, Jerome .

DERMATOLOGY, 2009, 219 (04) :299-302

[4] Staphylococcus aureus isolated in cases of impetigo produces both epidermolysin A or B and LukE-LukD in 78% of 131 retrospective and prospective cases [J].

Gravet, A ;

Meunier, O ;

Clyti, E ;

Moreau, B ;

Pradinaud, R ;

Monteil, H ;

Prévost, G .

JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (12) :4349-4356

[5] Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia [J].

Lina, G ;

Piémont, Y ;

Godail-Gamot, F ;

Bes, M ;

Peter, MO ;

Gauduchon, V ;

Vandenesch, F ;

Etienne, J .

CLINICAL INFECTIOUS DISEASES, 1999, 29 (05) :1128-1132

[6] Methicillin-resistant S-aureus infections among patients in the emergency department [J].

Moran, Gregory J. ;

Krishnadasan, Anusha ;

Gorwitz, Rachel J. ;

Fosheim, Gregory E. ;

McDougal, Linda K. ;

Carey, Roberta B. ;

Talan, David A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (07) :666-674

[7] Staphylococcus aureus positive for Panton-Valentine leukocidin genes but susceptible to methicillin in patients with furuncles [J].

Nolte, O ;

Haag, H ;

Zimmerman, A ;

Geiss, HK .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2005, 24 (07) :477-479

[8] Practice guidelines for the diagnosis and management of skin and soft-tissue infections [J].

Stevens, DL ;

Bisno, AL ;

Chambers, HF ;

Everett, ED ;

Dellinger, P ;

Goldstein, EJC ;

Gorbach, SL ;

Hirschmann, JV ;

Kaplan, EL ;

Montoya, JG ;

Wade, JC .

CLINICAL INFECTIOUS DISEASES, 2005, 41 (10) :1373-1406

[9] Staphylococcus aureus Panton-Valentine Leukocidin Contributes to Inflammation and Muscle Tissue Injury [J].

Tseng, Ching Wen ;

Kyme, Pierre ;

Low, Jennifer ;

Rocha, Miguel A. ;

Alsabeh, Randa ;

Miller, Loren G. ;

Otto, Michael ;

Arditi, Moshe ;

Diep, Binh An ;

Nizet, Victor ;

Doherty, Terence M. ;

Beenhouwer, David O. ;

Liu, George Y. .

PLOS ONE, 2009, 4 (07)

[10] Augmented Production of Panton-Valentine Leukocidin Toxin in Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Is Associated with Worse Outcome in a Murine Skin Infection Model [J].

Varshney, Avanish K. ;

Martinez, Luis R. ;

Hamilton, Stephanie M. ;

Bryant, Amy E. ;

Levi, Michael H. ;

Gialanella, Philip ;

Stevens, Dennis L. ;

Fries, Bettina C. .

JOURNAL OF INFECTIOUS DISEASES, 2010, 201 (01) :92-96

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