Panton-Valentine Leukocidin-Positive Staphylococcus aureus Strains Are Associated with Follicular Skin Infections

被引：18
作者：
Del Giudice, Pascal [1 ]
Bes, Michele [2 ,3 ,4 ]
Hubiche, Thomas
Blanc, Veronique [5 ]
Roudiere, Laurent
Lina, Gerard [2 ,3 ,4 ]
Vandenesch, Francois [2 ,3 ,4 ]
Etienne, Jerome [2 ,3 ,4 ]
机构：
[1] Hop Bonnet, Unite Malad Infect & Dermatol, Serv Infectiol Dermatol, FR-83700 Frejus, France
[2] Univ Lyon 1, Ctr Natl Reference Staphylocoques, F-69365 Lyon, France
[3] INSERM, U851, IFR128, F-69008 Lyon, France
[4] Hosp Civils Lyon, Ctr Biol Est, Bron, France
[5] Ctr Hosp dAntibes Juan Les Pins, Antibes, France
来源：
DERMATOLOGY | 2011年 / 222卷 / 02期
关键词：
Staphylococcus aureus; Panton-Valentine leukocidin; Abscess; Staphylococcal skin infection; Skin infection; VIRULENCE DETERMINANT; CUTANEOUS INFECTIONS; METHICILLIN; GENES;
D O I：
10.1159/000324044
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Background/Aims: Panton-Valentine leukocidin (PVL)-positive Staphylococcus aureus have been associated with suppurative infections; however, their precise role in skin infections has not been elucidated. We studied the rate of PVL-positive S. aureus in the different types of skin infections and compared follicular to nonfollicular skin infections. Methods: In our institution, patients with a skin infection caused by S. aureus were enrolled in a prospective, observational cohort study (from July 1, 2003 to June 30, 2010). We studied the rate of PVL-positive S. aureus in the different clinical types of skin infections and compared the rate of PVL-positive S. aureus in follicular infections to that in nonfollicular infections. Results: A total 229 skin infections were included: 97 (42.5%) were caused by PVL-positive strains. Thirty-nine of the 53 (74%) follicular infections [8 of the 17 (47%) with folliculitis, 30 of the 35 (85.5%) with furuncles and 1 with a carbuncle (100%)] were caused by PVL-positive S. aureus, compared to 16 of the 131 (12%) nonfollicular infections (p < 0.001). Conclusion: PVL-positive S. aureus strains are mainly associated with follicular skin infections. Copyright (C) 2011 S. Karger AG, Basel
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页码：167 / 170
页数：4
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