It is reported that Kerr-Newman and Kerr-Sen black holes are unstable to perturbations of charged massive scalar field. In this paper, we study analytically the complex frequencies which characterize charged massive scalar fields in a near-extremal Kerr-Sen black hole. For near-extremal Kerr-Sen black holes and for charged massive scalar fields in the eikonal large-mass M >> mu regime, where M is the mass of the black hole, and mu is the mass of the charged scalar field, we have obtained a simple expression for the dimensionless ratio omega(I)/ (omega(R) - omega(C) ), where omega(I) and omega(R) are, respectively, the imaginary and real parts of the frequency of the modes, and omega(c) is the critical frequency for the onset of super-radiance. We have also found our expression is consistent with the result of Hod [Phys. Rev. D 94, 044036 (2016)] for the case of a near-extremal Kerr-Newman black hole and the result of Zouros and Eardly [Ann. Phys. (N.Y.) 118, 139 (1979)] for the case of neutral scalar fields in the background of a near-extremal Kerr black hole.