Clean thoughts about dirty genes

被引：5
作者：
Van Gelder, RN
Hogenesch, JB
机构：
[1] Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA
[3] Genom Inst Novartis Res Fdn, La Jolla, CA USA
来源：
JOURNAL OF BIOLOGICAL RHYTHMS | 2004年 / 19卷 / 01期
关键词：
circadian rhythms; mouse strain; quantitative trait locus; epistasis; heterosis;
D O I：
10.1177/0748730403261123
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The mouse has joined the fruit fly, bread mold, and cyanobacteria as a tractable genetic system for studying mechanisms of circadian rhythms. The circadian rhythms of "knock-out" mice for specific clock genes, however, have demonstrated significant variability between laboratories. In this brief review, the authors discuss possible sources of this variability, focusing particularly on questions of modifier loci of circadian rhythms that vary between inbred mouse strains. They conclude with a short list of recommendations for researchers working on circadian rhythms in mixed-strain mice.
引用
收藏
页码：3 / 9
页数：7
相关论文
共 49 条
[1]   Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock [J].
Bae, K ;
Jin, XW ;
Maywood, ES ;
Hastings, MH ;
Reppert, SM ;
Weaver, DR .
NEURON, 2001, 30 (02) :525-536
[2]   QTL analysis and genomewide mutagenesis in mice: Complementary genetic approaches to the dissection of complex traits - Commentary [J].
Belknap, JK ;
Hitzemann, R ;
Crabbe, JC ;
Phillips, TJ ;
Buck, KJ ;
Williams, RW .
BEHAVIOR GENETICS, 2001, 31 (01) :5-15
[3]   GENETIC DISSECTION OF BEHAVIOR [J].
BENZER, S .
SCIENTIFIC AMERICAN, 1973, 229 (06) :24-37
[4]   Altered behavioral rhythms and clock gene expression in mice with a targeted mutation in the Period1 gene [J].
Cermakian, N ;
Monaco, L ;
Pando, MP ;
Dierich, A ;
Sassone-Corsi, P .
EMBO JOURNAL, 2001, 20 (15) :3967-3974
[5]   Influences of laboratory environment on behavior [J].
Chesler, EJ ;
Wilson, SG ;
Lariviere, WR ;
Rodriguez-Sas, S ;
Mogil, JS .
NATURE NEUROSCIENCE, 2002, 5 (11) :1101-1102
[6]   Identification and ranking of genetic and laboratory environment factors influencing a behavioral trait, thermal nociception, via computational analysis of a large data archive [J].
Chesler, EJ ;
Wilson, SG ;
Lariviere, WR ;
Rodriguez-Zas, SL ;
Mogil, JS .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2002, 26 (08) :907-923
[7]   Genetics of mouse behavior: Interactions with laboratory environment [J].
Crabbe, JC ;
Wahlsten, D ;
Dudek, BC .
SCIENCE, 1999, 284 (5420) :1670-1672
[8]   Assembling a clock for all seasons:: Are there M and E oscillators in the genes? [J].
Daan, S ;
Albrecht, U ;
van der Horst, GTJ ;
Illnerová, H ;
Roenneberg, T ;
Wehr, TA ;
Schwartz, WJ .
JOURNAL OF BIOLOGICAL RHYTHMS, 2001, 16 (02) :105-116
[9]   Altered patterns of sleep and behavioral adaptability in NPAS2-defficient mice [J].
Dudley, CA ;
Erbel-Sieler, C ;
Estill, SJ ;
Reick, M ;
Franken, P ;
Pitts, S ;
McKnight, SL .
SCIENCE, 2003, 301 (5631) :379-383
[10]   Genetic and molecular analysis of circadian rhythms [J].
Dunlap, JC .
ANNUAL REVIEW OF GENETICS, 1996, 30 :579-601
12345