Transition-Metal-Free Direct anti-Carboboration of Alkynes with Boronic Acids To Produce Alkenylheteroarenes

被引：33

作者：

Roscales, Silvia ^{[1
]}

Csakye, Aurelio G. ^{[1
]}

机构：

[1] Univ Complutense Madrid, Inst Pluridisciplinar, E-28040 Madrid, Spain

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 06期

关键词：

PALLADIUM-CATALYZED ADDITION; ARYLBORONIC ACIDS; CONJUGATE ADDITION; CARBOXYLIC-ACIDS; INTRAMOLECULAR CYANOBORATION; STEREOSELECTIVE-SYNTHESIS; TRISUBSTITUTED ALKENES; DIRECT ALKENYLATION; INTERNAL ALKYNES; RHODIUM;

D O I：

10.1021/acs.orglett.5b00517

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The transition-metal-free intermolecular direct 1,2-carboboration reaction of heteroarylacetylenes using boronic acids as reagents is achieved by utilizing tartaric acid as promoter. The reaction proceeds with excellent regioselectivity and anti stereoselectivity to afford boroxole frameworks. The resulting compounds are of use for the stereoselective preparation of polysubstituted alkenylheteroarenes.

引用

页码：1605 / 1608

页数：4

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