Drug Resistance and Novel Therapeutic Approaches in Invasive Candidiasis

被引:58
作者
Murphy, Sarah E. [1 ]
Bicanic, Tihana [1 ,2 ]
机构
[1] St Georges Univ London, Inst Infect & Immun, London, England
[2] St Georges Univ Hosp Natl Hlth Serv NHS Fdn Trust, Clin Acad Grp Infect & Immun, London, England
关键词
Candida; invasive candidiasis; candidaemia; antifungal resistance; antifungal drugs; drug therapy; drug resistance; antimicrobial resistance; BROAD-SPECTRUM ANTIFUNGAL; GLUCAN SYNTHASE INHIBITOR; LONG-ACTING ECHINOCANDIN; IN-VITRO ACTIVITY; INFECTIOUS-DISEASES SOCIETY; CELECOXIB DERIVATIVE AR-12; HIGHLY POTENT INHIBITOR; AMPHOTERICIN-B; MURINE MODEL; TREHALOSE-6-PHOSPHATE PHOSPHATASE;
D O I
10.3389/fcimb.2021.759408
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Candida species are the leading cause of invasive fungal infections worldwide and are associated with acute mortality rates of ~50%. Mortality rates are further augmented in the context of host immunosuppression and infection with drug-resistant Candida species. In this review, we outline antifungal drugs already in clinical use for invasive candidiasis and candidaemia, their targets and mechanisms of resistance in clinically relevant Candida species, encompassing not only classical resistance, but also heteroresistance and tolerance. We describe novel antifungal agents and targets in pre-clinical and clinical development, including their spectrum of activity, antifungal target, clinical trial data and potential in treatment of drug-resistant Candida. Lastly, we discuss the use of combination therapy between conventional and repurposed agents as a potential strategy to combat the threat of emerging resistance in Candida.
引用
收藏
页数:22
相关论文
共 235 条
[111]   CALCINEURIN IS A COMMON TARGET OF CYCLOPHILIN-CYCLOSPORINE-A AND FKBP-FK506 COMPLEXES [J].
LIU, J ;
FARMER, JD ;
LANE, WS ;
FRIEDMAN, J ;
WEISSMAN, I ;
SCHREIBER, SL .
CELL, 1991, 66 (04) :807-815
[112]   Genome-wide expression and location analyses of the Candida albicans Tac1p regulon [J].
Liu, Teresa T. ;
Znaidi, Sadri ;
Barker, Katherine S. ;
Xu, Lijing ;
Homayouni, Ramin ;
Saidane, Saloua ;
Morschhauser, Joachim ;
Nantel, Andre ;
Raymond, Martine ;
Rogers, P. David .
EUKARYOTIC CELL, 2007, 6 (11) :2122-2138
[113]   Characterization of In Vitro Resistance Development to the Novel Echinocandin CD101 in Candida Species [J].
Locke, Jeffrey B. ;
Almaguer, Amanda L. ;
Zuill, Douglas E. ;
Bartizal, Ken .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 60 (10) :6100-6107
[114]   Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses [J].
Lockhart, Shawn R. ;
Etienne, Kizee A. ;
Vallabhaneni, Snigdha ;
Farooqi, Joveria ;
Chowdhary, Anuradha ;
Govender, Nelesh P. ;
Colombo, Arnaldo Lopes ;
Calvo, Belinda ;
Cuomo, Christina A. ;
Desjardins, Christopher A. ;
Berkow, Elizabeth L. ;
Castanheira, Mariana ;
Magobo, Rindidzani E. ;
Jabeen, Kauser ;
Asghar, Rana J. ;
Meis, Jacques F. ;
Jackson, Brendan ;
Chiller, Tom ;
Litvintseva, Anastasia P. .
CLINICAL INFECTIOUS DISEASES, 2017, 64 (02) :134-140
[115]   A REVIEW OF COMPLICATIONS OF AMPHOTERICIN-B THERAPY - RECOMMENDATIONS FOR PREVENTION AND MANAGEMENT [J].
MADDUX, MS ;
BARRIERE, SL .
DRUG INTELLIGENCE & CLINICAL PHARMACY, 1980, 14 (03) :177-181
[116]  
Mansbach R, 2017, Open Forum Infect Dis, V4, pS472, DOI [10.1093/ofid/ofx163.1209, DOI 10.1093/OFID/OFX163.1209]
[117]   Fluconazole plus cyclosporine:: A fungicidal combination effective against experimental endocarditis due to Candida albicans [J].
Marchetti, O ;
Entenza, JM ;
Sanglard, D ;
Bille, J ;
Glauser, MP ;
Moreillon, P .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (11) :2932-2938
[118]   Potent synergism of the combination of fluconazole and cyclosporine in Candida albicans [J].
Marchetti, O ;
Moreillon, P ;
Glauser, MP ;
Bille, J ;
Sanglard, D .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (09) :2373-2381
[119]   Inducible azole resistance associated with a heterogeneous phenotype in Candida albicans [J].
Marr, KA ;
Lyons, CN ;
Ha, K ;
Rustad, TR ;
White, TC .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (01) :52-59
[120]   Role of trehalose in resistance to macrophage killing:: study with a tps1/tps1 trehalose-deficient mutant of Candida albicans [J].
Martinez-Esparza, M. ;
Aguinaga, A. ;
Gonzalez-Parraga, P. ;
Garcia-Penarrubia, P. ;
Jouault, T. ;
Argueelles, J. C. .
CLINICAL MICROBIOLOGY AND INFECTION, 2007, 13 (04) :384-394