Candida species are the leading cause of invasive fungal infections worldwide and are associated with acute mortality rates of ~50%. Mortality rates are further augmented in the context of host immunosuppression and infection with drug-resistant Candida species. In this review, we outline antifungal drugs already in clinical use for invasive candidiasis and candidaemia, their targets and mechanisms of resistance in clinically relevant Candida species, encompassing not only classical resistance, but also heteroresistance and tolerance. We describe novel antifungal agents and targets in pre-clinical and clinical development, including their spectrum of activity, antifungal target, clinical trial data and potential in treatment of drug-resistant Candida. Lastly, we discuss the use of combination therapy between conventional and repurposed agents as a potential strategy to combat the threat of emerging resistance in Candida.
机构:
Jersey City, SCYNEXIS Inc, Clin Dev, Jersey City, NJ USA
SCYNEXIS Inc, Clin Dev, Jersey City, NJ 07302 USAJersey City, SCYNEXIS Inc, Clin Dev, Jersey City, NJ USA
Azie, Nkechi
;
Angulo, David
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机构:
Jersey City, SCYNEXIS Inc, Clin Dev, Jersey City, NJ USA
SCYNEXIS Inc, Clin Dev, Jersey City, NJ 07302 USAJersey City, SCYNEXIS Inc, Clin Dev, Jersey City, NJ USA
Angulo, David
;
Dehn, Barbara
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机构:
El Camino Med Grp, Clin Dev, Mountain View, CA USAJersey City, SCYNEXIS Inc, Clin Dev, Jersey City, NJ USA
Dehn, Barbara
;
Sobel, Jack D.
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机构:
Wayne State Univ, Sch Med, Detroit, MI USAJersey City, SCYNEXIS Inc, Clin Dev, Jersey City, NJ USA
机构:
Jersey City, SCYNEXIS Inc, Clin Dev, Jersey City, NJ USA
SCYNEXIS Inc, Clin Dev, Jersey City, NJ 07302 USAJersey City, SCYNEXIS Inc, Clin Dev, Jersey City, NJ USA
Azie, Nkechi
;
Angulo, David
论文数: 0引用数: 0
h-index: 0
机构:
Jersey City, SCYNEXIS Inc, Clin Dev, Jersey City, NJ USA
SCYNEXIS Inc, Clin Dev, Jersey City, NJ 07302 USAJersey City, SCYNEXIS Inc, Clin Dev, Jersey City, NJ USA
Angulo, David
;
Dehn, Barbara
论文数: 0引用数: 0
h-index: 0
机构:
El Camino Med Grp, Clin Dev, Mountain View, CA USAJersey City, SCYNEXIS Inc, Clin Dev, Jersey City, NJ USA
Dehn, Barbara
;
Sobel, Jack D.
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Sch Med, Detroit, MI USAJersey City, SCYNEXIS Inc, Clin Dev, Jersey City, NJ USA