Microemulsion and bovine serum albumin nanoparticles as a novel hybrid nanocarrier system for efficient multifunctional drug delivery

被引：27
作者：
Gharbavi, Mahmoud [1 ,2 ]
Danafar, Hossein [2 ,3 ]
Sharafi, Ali [2 ]
机构：
[1] Zanjan Univ Med Sci, Student Comm Res, Zanjan, Iran
[2] Zanjan Univ Med Sci, Zanjan Pharmaceut Biotechnol Res Ctr, Zanjan, Iran
[3] Zanjan Univ Med Sci, Sch Pharm, Pharmaceut Nanotechnol Dept, Zanjan, Iran
来源：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2020年 / 108卷 / 08期
关键词：
bovine serum albumin nanoparticles (BSANPs); drug release kinetic; microemulsion; multifunctional drug delivery; paclitaxel; IN-VIVO; CREMOPHOR EL; OIL; PACLITAXEL; BEHAVIOR; RELEASE; VITRO; SURFACTANTS; POLYOLS; CANCER;
D O I：
10.1002/jbm.a.36935
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The present study aims to: (a) design the versatile microemulsions (MEs) system for drug delivery; (b) use the bovine serum albumin nanoparticles for MEs system development; (c) characterize the physicochemical properties, cytotoxicity, and biocompatibility of the modified MEs (MMEs) system; (d) load of paclitaxel (PTX) and folate conjugate of MEs system; and (e) assess the potential of anticancer activity of MEs system. The physicochemical possessions, in vitro and in vivo cytotoxicity, and stability of MMEs system were characterized. The results of our study show that the MEs system was stable, having narrow particle size distribution, nontoxic, biocompatible, and not active for leukocyte proliferation. So it can be concluded that the MMEs system as a promising candidate for a targeted multifunctional drug delivery system (PTX and folate) that is called a smart MEs system.
引用
收藏
页码：1688 / 1702
页数：15
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