Decreased expression of LncRNA MIR31HG in human bladder cancer

被引：45

作者：

He, Anbang ^{[1
,2
]}

Chen, Zhicong ^{[2
,3
]}

Mei, Hongbing ^{[1
,2
]}

Liu, Yuchen ^{[2
]}

机构：

[1] Anhui Med Univ, Shenzhen Peoples Hosp 2, Clin Med Coll, Shenzhen, Guangdong, Peoples R China

[2] Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Key Lab Med Reprogramming Technol, Shenzhen 518035, Guangdong, Peoples R China

[3] Shantou Univ, Coll Med, Shantou, Guangdong, Peoples R China

来源：

CANCER BIOMARKERS | 2016年 / 17卷 / 02期

基金：

中国国家自然科学基金;

关键词：

MIR31HG; LOC554202; bladder cancer; LncRNAs; LONG NONCODING RNA; LOC554202; PROLIFERATION; CHEMOTHERAPY; APOPTOSIS; MIGRATION; PROSTATE; MIR-31;

D O I：

10.3233/CBM-160635

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

OBJECTIVE: In this study, we examined the relationships between the expression level of long non-coding RNA MIR31HG in bladder cancer and the clinical characteristics. METHODS: A total of 55 tissue samples from patients with bladder cancer were collected, and the lncRNA MIR31HG levels in cancer, paired non-cancer tissues and BC cell lines were detected by real-time quantitative RT-PCR (qRT-PCR). The relationships between MIR31HG level and the clinical characteristics were evaluated. RESULTS: MIR31HG expression was remarkably decreased in bladder cancer tissues compared with adjacent noncancerous tissues (P < 0.05). MIR31HG expression was also significantly down-regulated in four bladder cancer cell lines (P < 0.001). Clinicopathologic analysis revealed that MIR31HG expression was negatively associated with TNM stage (P = 0.010), but not with other clinicopathological characteristics. CONCLUSIONS: These findings revealed that MIR31HG may function as a cancer-suppressor gene to participate in the bladder cancer carcinogenesis and development.

引用

页码：231 / 236

页数：6

共 18 条

[1]

[Anonymous], TUMOUR BIOL

[2]

[Anonymous], ONCOTARGET

[3]

[Anonymous], ONCOGENE

[4] miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer [J].

Augoff, Katarzyna ;

McCue, Brian ;

Plow, Edward F. ;

Sossey-Alaoui, Khalid .

MOLECULAR CANCER, 2012, 11

[5] Downregulation of miR-205 and miR-31 confers resistance to chemotherapy-induced apoptosis in prostate cancer cells [J].

Bhatnagar, N. ;

Li, X. ;

Padi, S. K. R. ;

Zhang, Q. ;

Tang, M-S ;

Guo, B. .

CELL DEATH & DISEASE, 2010, 1 :e105-e105

[6] Long non-coding RNA Loc554202 induces apoptosis in colorectal cancer cells via the caspase cleavage cascades [J].

Ding, Jie ;

Lu, Binbin ;

Wang, Jianping ;

Wang, Juan ;

Shi, Yongguo ;

Lian, Yifan ;

Zhu, Ya ;

Wang, Jirong ;

Fan, Yingrui ;

Wang, Zhaoxia ;

De, Wei ;

Wang, Keming .

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2015, 34

[7] MicroRNA-200c and microRNA-31 regulate proliferation, colony formation, migration and invasion in serous ovarian cancer [J].

Ibrahim, Fateen Farhana ;

Jamal, Rahman ;

Syafruddin, Saiful Effendi ;

Ab Mutalib, Nurul Syakima ;

Saidin, Sazuita ;

MdZin, Reena Rahayu ;

Mollah, Mohammad Manir Hossain ;

Mokhtar, Norfilza Mohd .

JOURNAL OF OVARIAN RESEARCH, 2015, 8

[8] LncRNAs and neoplasia [J].

Isin, Mustafa ;

Dalay, Nejat .

CLINICA CHIMICA ACTA, 2015, 444 :280-288

[9]

Jemal A, 2009, CA-CANCER J CLIN, V59, P225, DOI [10.3322/caac.20006, 10.3322/caac.21254, 10.3322/caac.21332, 10.3322/caac.21551, 10.3322/caac.20073, 10.3322/caac.21387, 10.3322/caac.21654, 10.3322/caac.21601]

[10] Long Noncoding RNA in Prostate, Bladder, and Kidney Cancer [J].

Martens-Uzunova, Elena S. ;

Bottcher, Rene ;

Croce, Carlo M. ;

Jenster, Guido ;

Visakorpi, Tapio ;

Calin, George A. .

EUROPEAN UROLOGY, 2014, 65 (06) :1140-1151

← 1 2 →