Patients with autoimmune polyendocrine syndrome type 1 have an increased susceptibility to severe herpesvirus infections

被引：33

作者：

Hetemaki, Iivo ^{[1
,2
,3
]}

Laakso, Saila ^{[3
,4
,5
]}

Valimaa, Hannamari ^{[3
,6
,7
]}

Kleino, Iivari ^{[2
,3
]}

Kekalainen, Eliisa ^{[1
,2
,3
]}

Makitie, Outi ^{[3
,4
,5
,8
]}

Arstila, T. Petteri ^{[1
,2
,3
]}

机构：

[1] Univ Helsinki, Dept Bacteriol & Immunol, Helsinki, Finland

[2] Univ Helsinki, Translat Immunol Res Program, Helsinki, Finland

[3] Helsinki Univ Hosp, Helsinki, Finland

[4] Folkhalsan Inst Genet, Helsinki, Finland

[5] Univ Helsinki, Childrens Hosp, Helsinki, Finland

[6] Univ Helsinki, Dept Virol, Helsinki, Finland

[7] Univ Helsinki, Dept Oral & Maxillofacial Surg, Helsinki, Finland

[8] Karolinska Inst, Karolinska Univ Hosp, Dept Mol Med, Clin Genet, Stockholm, Sweden

来源：

CLINICAL IMMUNOLOGY | 2021年 / 231卷

基金：

芬兰科学院;

关键词：

AIRE; Herpes simplex; Varicella zoster; Herpes zoster; Autoantibody; Immunodeficiency; Type I interferon; CHRONIC MUCOCUTANEOUS CANDIDIASIS; AUTOANTIBODIES; VARICELLA; PREVENTION;

D O I：

10.1016/j.clim.2021.108851

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Almost all patients with autoimmune polyendocrine syndrome type 1 (APS-1) have neutralizing antibodies against type 1 interferons (IFN), important mediators of antiviral defense. Recently, neutralizing anti-IFN antibodies were shown to be a risk factor of severe COVID-19. Here we show in a cohort of 44 patients with APS-1 that higher titers of neutralizing anti-IFN alpha 4 antibodies are associated with a higher and earlier incidence of VZV reactivation (herpes zoster). The patients also present with uncommonly severe clinical sequelae of herpetic infections. APS-1 patients had decreased humoral immune responses to varicella zoster virus, but cellular responses were comparable to healthy controls. These results suggest that blocking the type I interferon pathway in patients with APS-1 patients leads to a clinically significant immune deficiency, and susceptibility to herpesviruses should be taken into account when treating patients with APS-1.

引用

页数：6

共 29 条

[1] Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1 [J].

Bastard, Paul ;

Orlova, Elizaveta ;

Sozaeva, Leila ;

Levy, Romain ;

James, Alyssa ;

Schmitt, Monica M. ;

Ochoa, Sebastian ;

Kareva, Maria ;

Rodina, Yulia ;

Gervais, Adrian ;

Le Voyer, Tom ;

Rosain, Jeremie ;

Philippot, Quentin ;

Neehus, Anna-Lena ;

Shaw, Elana ;

Migaud, Melanie ;

Bizien, Lucy ;

Ekwall, Olov ;

Berg, Stefan ;

Beccuti, Guglielmo ;

Ghizzoni, Lucia ;

Thiriez, Gerard ;

Pavot, Arthur ;

Goujard, Cecile ;

Fremond, Marie-Louise ;

Carter, Edwin ;

Rothenbuhler, Anya ;

Linglart, Agnes ;

Mignot, Brigite ;

Comte, Aurelie ;

Cheikh, Nathalie ;

Hermine, Olivier ;

Breivik, Lars ;

Husebye, Eystein S. ;

Humbert, Sebastien ;

Rohrlich, Pierre ;

Coaquette, Alain ;

Vuoto, Fanny ;

Faure, Karine ;

Mahlaoui, Nizar ;

Kotnik, Primoz ;

Battelino, Tadej ;

Podkrajsek, Katarina Trebusak ;

Kisand, Kai ;

Ferre, Elise M. N. ;

DiMaggio, Thomas ;

Rosen, Lindsey B. ;

Burbelo, Peter D. ;

McIntyre, Martin ;

Kann, Nelli Y. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2021, 218 (07)

[2] Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine [J].

Bastard, Paul ;

Michailidis, Eleftherios ;

Hoffmann, Hans-Heinrich ;

Chbihi, Marwa ;

Le Voyer, Tom ;

Rosain, Jeremie ;

Philippot, Quentin ;

Seeleuthner, Yoann ;

Gervais, Adrian ;

Materna, Marie ;

Nunes de Oliveira, Patricia Mouta ;

Maia, Maria de Lourdes S. ;

Ano Bom, Ana Paula Dinis ;

Azamor, Tamiris ;

da Conceicao, Deborah Araujo ;

Goudouris, Ekaterini ;

Homma, Akira ;

Slesak, Gunther ;

Schaefer, Johannes ;

Pulendran, Bali ;

Miller, Joseph D. ;

Huits, Ralph ;

Yang, Rui ;

Rosen, Lindsey B. ;

Bizien, Lucy ;

Lorenzo, Lazaro ;

Chrabieh, Maya ;

Erazo, Lucia, V ;

Rozenberg, Flore ;

Jeljeli, Mohamed Maxime ;

Beziat, Vivien ;

Holland, Steven M. ;

Cobat, Aurelie ;

Notarangelo, Luigi D. ;

Su, Helen C. ;

Ahmed, Rafi ;

Puel, Anne ;

Zhang, Shen-Ying ;

Abel, Laurent ;

Seligman, Stephen J. ;

Zhang, Qian ;

MacDonald, Margaret R. ;

Jouanguy, Emmanuelle ;

Rice, Charles M. ;

Casanova, Jean-Laurent .

JOURNAL OF EXPERIMENTAL MEDICINE, 2021, 218 (04)

[3] Autoantibodies against type I IFNs in patients with life-threatening COVID-19 [J].

Bastard, Paul ;

Rosen, Lindsey B. ;

Zhang, Qian ;

Michailidis, Eleftherios ;

Hoffmann, Hans-Heinrich ;

Zhang, Yu ;

Dorgham, Karim ;

Philippot, Quentin ;

Rosain, Jeremie ;

Beziat, Vivien ;

Manry, Jeremy ;

Shaw, Elana ;

Haljasmagi, Liis ;

Peterson, Part ;

Lorenzo, Lazaro ;

Bizien, Lucy ;

Trouillet-Assant, Sophie ;

Dobbs, Kerry ;

de Jesus, Adriana Almeida ;

Belot, Alexandre ;

Kallaste, Anne ;

Catherinot, Emilie ;

Tandjaoui-Lambiotte, Yacine ;

Le Pen, Jeremie ;

Kerner, Gaspard ;

Bigio, Benedetta ;

Seeleuthner, Yoann ;

Yang, Rui ;

Bolze, Alexandre ;

Spaan, Andras N. ;

Delmonte, Ottavia M. ;

Abers, Michael S. ;

Aiuti, Alessandro ;

Casari, Giorgio ;

Lampasona, Vito ;

Piemonti, Lorenzo ;

Ciceri, Fabio ;

Bilguvar, Kaya ;

Lifton, Richard P. ;

Vasse, Marc ;

Smadja, David M. ;

Migaud, Melanie ;

Hadjadj, Jerome ;

Terrier, Benjamin ;

Duffy, Darragh ;

Quintana-Murci, Lluis ;

van de Beek, Diederik ;

Roussel, Lucie ;

Vinh, Donald C. ;

Tangye, Stuart G. .

SCIENCE, 2020, 370 (6515) :423-+

[4] Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency [J].

Bastard, Paul ;

Manry, Jeremy ;

Chen, Jie ;

Rosain, Jeremie ;

Seeleuthner, Yoann ;

AbuZaitun, Omar ;

Lorenzo, Lazaro ;

Khan, Taushif ;

Hasek, Mary ;

Hernandez, Nicholas ;

Bigio, Benedetta ;

Zhang, Peng ;

Levy, Romain ;

Shrot, Shai ;

Reino, Eduardo J. Garcia ;

Lee, Yoon-Seung ;

Boucherit, Soraya ;

Aubart, Melodie ;

Gijsbers, Rik ;

Beziat, Vivien ;

Li, Zhi ;

Pellegrini, Sandra ;

Rozenberg, Flore ;

Marr, Nico ;

Meyts, Isabelle ;

Boisson, Bertrand ;

Cobat, Aurelie ;

Bustamante, Jacinta ;

Zhang, Qian ;

Jouangy, Emmanuelle ;

Abel, Laurent ;

Somech, Raz ;

Casanova, Jean-Laurent ;

Zhang, Shen-Ying .

JOURNAL OF CLINICAL INVESTIGATION, 2021, 131 (01)

[5] Varicella recurrence complicated by pneumonia after liver transplantation for APECED [J].

Batra, Akshay ;

Davison, Suzanne ;

Rajwal, Sanjay ;

Hale, Antony ;

Stringer, Mark D. ;

McClean, Patricia .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2007, 44 (05) :637-639

[6] Anti-cytokine autoantibodies in postherpetic neuralgia [J].

Bayat, Ahmad ;

Burbelo, Peter D. ;

Browne, Sarah K. ;

Quinlivan, Mark ;

Martinez, Bianca ;

Holland, Steven M. ;

Buvanendran, Asokumar ;

Kroin, Jeffrey S. ;

Mannes, Andrew J. ;

Breuer, Judith ;

Cohen, Jeffrey I. ;

Iadarola, Michael J. .

JOURNAL OF TRANSLATIONAL MEDICINE, 2015, 13

[7] A COVID-19 pneumonia case report of autoimmune polyendocrine syndrome type 1 in Lombardy, Italy: letter to the editor [J].

Beccuti, G. ;

Ghizzoni, L. ;

Cambria, V. ;

Codullo, V. ;

Sacchi, P. ;

Lovati, E. ;

Mongodi, S. ;

Iotti, G. A. ;

Mojoli, F. .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2020, 43 (08) :1175-1177

[8] Patients With APECED Have Increased Early Mortality Due to Endocrine Causes, Malignancies and infections [J].

Borchers, Joonatan ;

Pukkala, Eero ;

Makitie, Outi ;

Laakso, Saila .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2020, 105 (06) :E2207-E2213

[9]

Fiore Anthony E., 2007, Morbidity and Mortality Weekly Report, V56, P1

[10] Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus [J].

Furie, Richard ;

Khamashta, Munther ;

Merrill, Joan T. ;

Werth, Victoria P. ;

Kalunian, Kenneth ;

Brohawn, Philip ;

Illei, Gabor G. ;

Drappa, Jorn ;

Wang, Liangwei ;

Yoo, Stephen .

ARTHRITIS & RHEUMATOLOGY, 2017, 69 (02) :376-386

← 1 2 3 →