Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library

被引：27
|
作者：
Sun, Dianqing [1 ]
Jones, Victoria [2 ]
Carson, Elizabeth I. [1 ]
Lee, Robin E. B. [1 ]
Scherman, Michael S. [2 ]
McNeil, Michael R. [2 ]
Lee, Richard E. [1 ]
机构：
[1] Univ Tennessee, Ctr Hlth Sci, Dept Pharmaceut Sci, Memphis, TN 38163 USA
[2] Colorado State Univ, Dept Microbiol, Ft Collins, CO 80523 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 24期
关键词：
mureidomycins; uridine-based library; solid-phase synthesis; IRORI technology; anti-tuberculosis activity; tuberculosis; antibiotic;
D O I：
10.1016/j.bmcl.2007.09.097
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A 1000-member uridinyl branched peptide library was synthesized on PS-DES support using IRORI technology. Highthroughput screening of this library for anti -tuberculosis activity identified several members with a MIC90 value of 12.5 mu g/mL. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6899 / 6904
页数：6
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