Biomechanical determinants of abdominal aortic aneurysm rupture

被引:199
作者
Vorp, DA
Geest, JPV
机构
[1] Univ Pittsburgh, Dept Surg, McGowan Inst Regenerat Med, Pittsburgh, PA 15219 USA
[2] Univ Pittsburgh, Dept Bioengn, Div Vasc Surg, Pittsburgh, PA 15219 USA
关键词
abdominal aortic aneurysm; biomechanics; rupture; strength; stress;
D O I
10.1161/01.ATV.0000174129.77391.55
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Rupture of abdominal aortic aneurysm (AAA) represents a significant clinical event, having a mortality rate of 90% and being currently ranked as the 13th leading cause of death in the US. The ability to reliably evaluate the susceptibility of a particular AAA to rupture on a case-specific basis could vastly improve the clinical management of these patients. Because AAA rupture represents a mechanical failure of the degenerated aortic wall, biomechanical considerations are important to understand this process and to improve our predictions of its occurrence. Presented here is an overview of research to date related to the biomechanics of AAA rupture. This includes a summary of results related to ex vivo and in vivo mechanical testing, noninvasive AAA wall stress estimations, and potential mechanisms of AAA wall weakening. We conclude with a demonstration of a biomechanics-based approach to predicting AAA rupture on a patient-specific basis, which may ultimately prove to be superior to the widely and currently used maximum diameter criterion.
引用
收藏
页码:1558 / 1566
页数:9
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