The transcription factor BATF modulates cytokine-mediated responses in T cells

被引：26

作者：

Sopel, Nina ^{[1
]}

Graser, Anna ^{[1
]}

Mousset, Stephanie ^{[1
]}

Finotto, Susetta ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Mol Pneumol, Hartmannstr 14,Room 0-011, D-91052 Erlangen, Germany

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2016年 / 30卷

关键词：

AP-1; BATF; T cells; Asthma; ATF-LIKE BATF; ACTIVATOR PROTEIN-1; DIFFERENTIATION CHECKPOINT; NEGATIVE REGULATOR; GENE-EXPRESSION; MAST-CELLS; B-CELLS; AP-1; ASTHMA; EFFECTOR;

D O I：

10.1016/j.cytogfr.2016.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transcription factor BATF (basic leucine zipper transcription factor, ATF-tike), belongs to the AP-1 family of transcription factors and has been shown to be predominantly expressed in cells of haematopoietic origin, especially in B and T cells. In studies using Batf-deficient mice, a profound defect in the differentiation of T helper cells type 17 (Th17) and follicular T helper cells (Tfh) was described, as well as an impairment of antibody production with switched isotypes. More recently BATF has been described to influence also Th2 and Th9 responses in models of murine experimental asthma. In CD8(+) T cells BATF has been found associated with anti-viral responses. This review summarizes the role of BATF in CD4(+) T cell subsets and in CD8(+) T cells, with particular focus on this transcription factor in the setting of allergic asthma. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：39 / 45

页数：7

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