Molybdenum disulphide (MoS2) is a transition metal dichalcogenide most widely studied as a heterogeneous catalyst due to its outstanding structural and physicochemical properties. Today, 2D layered MoS2 has gained much attention due to its variety of environmental remediation applications, production of cleaner fuels, and energy storage. MoS2 is a structural analogue of graphene and has similar properties, like greater surface area, a good charge carrying capacity, and higher mechanical strength. Therefore, MoS2 can be easily coupled with graphene to further enhancing its catalytic efficiencies. Moreover, MoS2 is less costly, highly abundant, has better light absorption capacity and adjustable bandgap than graphene. Most of the recent advancements in structural and synthesis techniques for improving catalytic properties of MoS2 for various applications like photo-degradation of dyes and organic compounds, hydrogen production, dye-sensitized solar cells, electrochemical capacitors, hydrodesulfurization, chemical and biological sensors, and gas sensors are discussed in this paper. Future prospective and research topics for the development of MoS2 based composites are also discussed.