Expression of heat shock protein (Hsp) 70 and Hsp 40 in gastric cancer

被引：92
|
作者：
Isomoto, H
Oka, M
Yano, Y
Kanazawa, Y
Soda, H
Terada, R
Yasutake, T
Nakayama, T
Shikuwa, S
Takeshima, F
Udono, H
Murata, I
Ohtsuka, K
Kohno, S
机构：
[1] Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki 8528501, Japan
[2] Nagasaki Univ, Sch Med, Dept Surg 1, Nagasaki 8528501, Japan
[3] Nagasaki Univ, Sch Med, Atom Bomb Inst, Dept Pathol, Nagasaki 8528501, Japan
[4] Natl Nagasaki Med Ctr, Dept Endoscopy, Omura, Japan
[5] Nagasaki Univ, Sch Med, Dept Immunol, Nagasaki 852, Japan
[6] Nagasaki Univ, Grad Sch Biomed Sci, Dept Pharmacotherapeut, Nagasaki, Japan
[7] Chubu Univ, Coll Biosci & Biotechnol, Lab Cell & Stress Biol, Kasugai, Aichi, Japan
来源：
CANCER LETTERS | 2003年 / 198卷 / 02期
关键词：
heat shock protein 70; heat shock protein 40; gastric cancer; immunohistochemistry; immunoblot;
D O I：
10.1016/S0304-3835(03)00305-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Heat shock proteins (Hsp) 70 and Hsp 40 are stress proteins that cooperate as chaperones in mammalian cells. We determined the expression of Hsp 70 and Hsp 40 in 81 gastric cancers. Immunoreactivities to Hsp 70 and Hsp 40 were detected in 67.9 and 22.2% of tumors, respectively. Immunohistochemical analysis showed enhanced Hsp 70 and Hsp 40 expression in gastric tumor tissue, relative to the surrounding normal tissue. Overexpression of Hsp 70 and Hsp 40 was also confirmed by immunoblotting. Among various clinicopathological parameters, low histopathological differentiation was associated with reduced expression of both proteins. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：219 / 228
页数：10
相关论文
共 50 条
  • [1] Expression of heat shock protein (Hsp) 70 and Hsp 40 in colorectal cancer
    Kanazawa, Y
    Isomoto, H
    Oka, M
    Yano, Y
    Soda, H
    Shikuwa, S
    Takeshima, F
    Omagari, K
    Mizuta, Y
    Murase, K
    Nakagoe, T
    Ohtsuka, K
    Kohno, S
    MEDICAL ONCOLOGY, 2003, 20 (02) : 157 - 164
  • [2] Expression of heat shock protein (Hsp) 70 and Hsp 40 in colorectal cancer
    Yusei Kanazawa
    Hajime Isomoto
    Mikio Oka
    Yoshitsugu Yano
    Hiroshi Soda
    Saburo Shikuwa
    Fuminao Takeshima
    Katsuhisa Omagari
    Yohei Mizuta
    Kunihiko Murase
    Toru Nakagoe
    Kenzo Ohtsuka
    Shigeru Kohno
    Medical Oncology, 2003, 20 : 157 - 164
  • [3] Heat shock protein 70 (HSP70) expression is associated with poor prognosis in intestinal type gastric cancer
    Lee, Hyoun Wook
    Lee, Eun Hee
    Kim, Seok-Hyun
    Roh, Mee Sook
    Jung, Sang Bong
    Choi, Young Cheol
    VIRCHOWS ARCHIV, 2013, 463 (04) : 489 - 495
  • [4] Heat shock protein 70 (HSP70) expression is associated with poor prognosis in intestinal type gastric cancer
    Hyoun Wook Lee
    Eun Hee Lee
    Seok-Hyun Kim
    Mee Sook Roh
    Sang Bong Jung
    Young Cheol Choi
    Virchows Archiv, 2013, 463 : 489 - 495
  • [5] Expression and prognostic examination of heat shock proteins (HSP 27, HSP 70, and HSP 90) in medulloblastoma
    Hauser, Peter
    Hanzely, Zoltan
    Jakab, Zsuzsanna
    Olah, Laszlone
    Szabo, Erika
    Jeney, Andras
    Schuler, Dezso
    Fekete, Gyorgy
    Bognar, Laszlo
    Garami, Miklos
    JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2006, 28 (07) : 461 - 466
  • [6] Overexpression of the heat shock protein HSP70 family and p53 protein and prognosis for patients with gastric cancer
    Maehara, Y
    Oki, E
    Abe, T
    Tokunaga, E
    Shibahara, K
    Kakeji, Y
    Sugimachi, K
    ONCOLOGY, 2000, 58 (02) : 144 - 151
  • [7] Expression of heat shock protein 70 (HSP70) in patients with colorectal adenocarcinoma - immunohistochemistry and Western blot analysis
    Milicevic, Z. T.
    Petkovic, M. Z.
    Drndarevic, N. C.
    Pavlovic, M. D.
    Todorovic, V. N.
    NEOPLASMA, 2007, 54 (01) : 37 - 45
  • [8] Strong expression of heat shock proteins in growth plate cartilage, an immunohistochemical study of HSP28, HSP70 and HSP110
    N. Vanmuylder
    L. Evrard
    N. Dourov
    Anatomy and Embryology, 1997, 195 : 359 - 362
  • [9] Sudden infant death syndrome: no significant expression of heat-shock proteins (HSP27, HSP70)
    Doberentz, Elke
    Fuehring, Sarah
    Madea, Burkhard
    FORENSIC SCIENCE MEDICINE AND PATHOLOGY, 2016, 12 (01) : 33 - 39
  • [10] Immunohistochemical detection of the inducible heat shock protein Hsp70: A methodological study
    Malusecka, E
    Zborek, A
    Krzyzowska-Gruca, S
    Krawczyk, Z
    JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2006, 54 (02) : 183 - 189
12345