Refutation of the hypothesis linking anti-acetylcholine receptor antibodies and tardive dyskinesias

被引：0

作者：

Granger, B

Garabedian, BVD

PoirierLittre, MF

Galinowski, A

Loo, H

机构：

[1] HOP NECKER ENFANTS MALAD,SERV IMMUNOL CLIN,CNRS,URA 122,INSERM,U25,F-75015 PARIS,FRANCE

[2] HOP ST ANNE,SERV HOSP UNIV SANTE MENTALE & THERAPEUT,F-75674 PARIS,FRANCE

来源：

ANNALES MEDICO-PSYCHOLOGIQUES | 1996年 / 154卷 / 05期

关键词：

anti-acetylcholine receptor antibodies; neuroleptic; tardive dyskinesia;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several cases of non-myasthenic sera containing anti-acetylcholine receptor antibodies (AChR-Ab) have been reported in patients treated with neuroleptic drugs and affected by tardive dyskinesia (TD) suggesting the possibility that the immune system was involved in this condition. We assayed sera for ACh-Ab in sera from 10 schizophrenics with TD (average age +/- SD : 39.7 +/- 13.3 years) and 10 schizophrenics without TD as controls (51.0 +/- 14.6 years), Abnormal AChR-Ab titers were never detected in patients with TD; one 48 years old patient in the control groupe had a threshold AChR-Ab levels (0.80 nM), It seems then that the link between AChR-Ab and TD is not substantiated by our study.

引用

页码：321 / 322

页数：2

共 8 条

[1] FALSE POSITIVE ANTIACETYLCHOLINE RECEPTOR ANTIBODIES IN MOTOR-NEURON DISEASE [J].