Protein nanoarrays - Aptamer-directed self-assembly of protein arrays on a DNA nanostructure

被引：167
|
作者：
Liu, Y
Lin, CX
Li, HY
Yan, H [1 ]
机构：
[1] Arizona State Univ, Dept Chem, Tempe, AZ 85287 USA
[2] Arizona State Univ, Biochem & Biodesign Inst, Tempe, AZ 85287 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 28期
关键词：
DNA structures; nanostructures; protein arrays; scanning probe microscopy; self-assembly;
D O I：
10.1002/anie.200501089
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Lined up nicely: The self-assembly of proteins on rationally designed nanostructures into periodic linear arrays has been demonstrated. Triple-crossover DNA tiles 1 containing an aptamer sequence (AS) to which thrombin specifically binds can form linear arrays 2. These direct the ultimate positioning of thrombin proteins (green spheres) in 3. This system should facilitate the construction of other such programmable nanoscale protein arrays. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：4333 / 4338
页数：6
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