Accuracy of serum LDH elevation for the diagnosis of Pneumocystis jiroveci pneumonia

被引：42

作者：

Vogel, Monika N. ^{[2
]}

Weissgerber, Patrick ^{[1
,3
]}

Goeppert, Benjamin ^{[4
]}

Hetzel, Juergen ^{[5
]}

Vatlach, Mignon ^{[2
]}

Claussen, Claus D. ^{[2
]}

Horger, Marius ^{[2
]}

机构：

[1] Univ Heidelberg, Dept Neuroradiol, DE-69120 Heidelberg, Germany

[2] Univ Tubingen, Dept Diagnost & Intervent Radiol, Tubingen, Germany

[3] Univ Tubingen, Inst Med Microbiol & Hyg, Tubingen, Germany

[4] Univ Heidelberg, Inst Pathol, D-6900 Heidelberg, Germany

[5] Univ Heidelberg, Dept Internal Med Oncol Pulmonol 2, D-6900 Heidelberg, Germany

来源：

SWISS MEDICAL WEEKLY | 2011年 / 141卷

关键词：

pneumonia; lactate dehydrognase; immunosuppression; immunodeficiency; serum test; accuracy; CARINII-PNEUMONIA; LACTATE-DEHYDROGENASE; IMMUNOCOMPROMISED PATIENTS; DISEASE;

D O I：

10.4414/smw.2011.13184

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In 328 immunocompromised patients, 105 with and 193 without Pneumocystis jiroveci pneumonia (PCP), serum lactate dehydrogenase (LDH) was analysed retrospectively, taking into consideration the time interval from the onset of symptoms to the start of specific therapy. 97 of the 105 PCP patients were negative for human immunodeficiency virus (HIV). Eight were positive. Of the 193 patients without PCP 134 were HIV-negative and 59 were HIV-positive. In HIV-negative patients the sensitivity of LDH elevation was 63% and specificity 43%. In HIV-positive patients sensitivity was 100% and specificity 47%. The overall accuracy of LDH for the diagnosis of PCP was 52%, 51% in HIV-negative and 58% in HIV-positive patients. Except for its sensitivity in HIV-positive patients, the value of LDH for the diagnosis of PCP should not be overestimated.

引用

页数：5

共 15 条

[1] Polymerase Chain Reaction for Diagnosing Pneumocystis Pneumonia in Non-HIV Immunocompromised Patients With Pulmonary Infiltrates [J].

Azoulay, Elie ;

Bergeron, Anne ;

Cheuret, Sylvie ;

Bele, Nicolas ;

Schlemmer, Benoit ;

Menotti, Jean .

CHEST, 2009, 135 (03) :655-661

[2] Utility of lactate dehydrogenase vs radiographic severity in the differential diagnosis of Pneumocystis carinii pneumonia [J].

Boldt, MJ ;

Bai, TR .

CHEST, 1997, 111 (05) :1187-1192

[3] Clinical picture of Pneumocystis jiroveci pneumonia in cancer patients [J].

Bollee, Guillaume ;

Sarfati, Claudine ;

Thiery, Guillaume ;

Bergeron, Anne ;

de Miranda, Sandra ;

Menotti, Jean ;

de Castro, Nathalie ;

Tazi, Abdellatif ;

Schlemmer, Benoit ;

Azoulay, Elie .

CHEST, 2007, 132 (04) :1305-1310

[4] PNEUMOCYSTIS-CARINII PNEUMONIA IN PATIENTS WITH CONNECTIVE-TISSUE DISEASE [J].

CHECHANI, V ;

BRIDGES, A .

CHEST, 1992, 101 (02) :375-378

[5] Acute respiratory failure due to Pneumocystis pneumonia in patients without human immunodeficiency virus infection - Outcome and associated features [J].

Festic, E ;

Gajic, O ;

Limper, AH ;

Aksamit, TR .

CHEST, 2005, 128 (02) :573-579

[6]

GLICK JH, 1969, AM J CLIN PATHOL, V52, P320

[7]

GRUDEN JF, HIGH RESOLUTION CT E

[8] Radiological Features of Pneumocystis jirovecii Pneumonia in Immunocompromised Patients with and Without AIDS [J].

Hardak, Emilia ;

Brook, Olga ;

Yigla, Mordechai .

LUNG, 2010, 188 (02) :159-163

[9] PNEUMOCYSTIS-CARINII PNEUMONIA - A COMPARISON BETWEEN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME AND PATIENTS WITH OTHER IMMUNODEFICIENCIES [J].

KOVACS, JA ;

HIEMENZ, JW ;

MACHER, AM ;

STOVER, D ;

MURRAY, HW ;

SHELHAMER, J ;

LANE, HC ;

URMACHER, C ;

HONIG, C ;

LONGO, DL ;

PARKER, MM ;

NATANSON, C ;

PARRILLO, JE ;

FAUCI, AS ;

PIZZO, PA ;

MASUR, H .

ANNALS OF INTERNAL MEDICINE, 1984, 100 (05) :663-671

[10] PNEUMOCYSTIS-CARINII PNEUMONIA - DIFFERENCES IN LUNG PARASITE NUMBER AND INFLAMMATION IN PATIENTS WITH AND WITHOUT AIDS [J].

LIMPER, AH ;

OFFORD, KP ;

SMITH, TF ;

MARTIN, WJ .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1989, 140 (05) :1204-1209

← 1 2 →