Qualitative investigation of the factors that generate ambivalent feelings in women who give birth after receiving negative results from non-invasive prenatal testing

被引：14

作者：

Yotsumoto, Junko ^{[1
]}

Sekizawa, Akihiko ^{[2
]}

Inoue, Satomi ^{[3
]}

Suzumori, Nobuhiro ^{[4
]}

Samura, Osamu ^{[5
]}

Yamada, Takahiro ^{[6
]}

Miura, Kiyonori ^{[7
]}

Masuzaki, Hideaki ^{[7
]}

Sawai, Hideaki ^{[8
]}

Murotsuki, Jun ^{[9
]}

Hamanoue, Haruka ^{[10
]}

Kamei, Yoshimasa ^{[11
]}

Endo, Toshiaki ^{[12
]}

Fukushima, Akimune ^{[13
]}

Katagiri, Yukiko ^{[14
]}

Takeshita, Naoki ^{[14
]}

Ogawa, Masaki ^{[15
]}

Nishizawa, Haruki ^{[16
]}

Okamoto, Yoko ^{[17
,18
]}

Tairaku, Shinya ^{[19
]}

Kaji, Takashi ^{[20
]}

Maeda, Kazuhisa ^{[21
]}

Matsubara, Keiichi ^{[22
]}

Ogawa, Masanobu ^{[23
]}

Osada, Hisao ^{[24
]}

Ohba, Takashi ^{[25
]}

Kawano, Yukie ^{[26
]}

Sasaki, Aiko ^{[27
]}

Sago, Haruhiko ^{[27
]}

机构：

[1] Int Univ Hlth & Welf, Grad Sch Hlth & Welf Sci, Dept Genet Counseling, 4-1-26 Minato Ku, Tokyo 1078402, Japan

[2] Showa Univ, Sch Med, Dept Obstet & Gynecol, Tokyo, Japan

[3] Natl Hosp Org Tokyo Med Ctr, Med Genet Ctr, Tokyo, Japan

[4] Nagoya City Univ, Div Clin & Mol Genet, Dept Obstet & Gynecol, Grad Sch Med Sci, Nagoya, Aichi, Japan

[5] Jikei Univ, Sch Med, Dept Obstet & Gynecol, Tokyo, Japan

[6] Kyoto Univ Hosp, Clin Genet Unit, Kyoto, Japan

[7] Nagasaki Univ, Grad Sch Biomed Sci, Dept Obstet & Gynecol, Nagasaki, Japan

[8] Hyogo Coll Med, Dept Obstet & Gynecol, Nishinomiya, Hyogo, Japan

[9] Tohoku Univ, Miyagi Childrens Hosp, Dept Maternal & Fetal Med, Grad Sch Med, Sendai, Miyagi, Japan

[10] Yokohama City Univ Med, Dept Clin Genet, Yokohama, Kanagawa, Japan

[11] Saitama Med Univ Hosp, Dept Obstet & Gynecol, Saitama, Japan

[12] Sapporo Med Univ, Dept Obstet & Gynecol, Sch Med, Sapporo, Hokkaido, Japan

[13] Iwate Med Univ, Sch Med, Dept Clin Genet, Morioka, Iwate, Japan

[14] Toho Univ, Fac Med, Dept Obstet & Gynecol, Tokyo, Japan

[15] Tokyo Womens Med Univ Hosp, Perinatal Med Ctr, Tokyo, Japan

[16] Fujita Hlth Univ, Dept Obstet & Gynecol, Toyoake, Aichi, Japan

[17] Osaka Med Ctr, Dept Obstet, Osaka, Japan

[18] Res Inst Maternal & Child Hlth, Osaka, Japan

[19] Kobe Univ, Grad Sch Med, Dept Obstet & Gynecol, Kobe, Hyogo, Japan

[20] Univ Tokushima, Fac Med, Dept Obstet & Gynecol, Tokushima, Japan

[21] Shikoku Med Ctr Children & Adults, Dept Obstet & Gynecol, Zentsuji, Kagawa, Japan

[22] Ehime Univ, Dept Obstet & Gynecol, Sch Med, Matsuyama, Ehime, Japan

[23] Natl Hosp Org Kyushu Med Ctr, Dept Obstet & Gynecol, Clin Res Inst, Fukuoka, Japan

[24] Chiba Univ Hosp, Dept Maternal Fetal Med, Chiba, Japan

[25] Kumamoto Univ, Dept Obstet & Gynecol, Kumamoto, Japan

[26] Oita Univ, Fac Med, Dept Mol Pathol, Oita, Japan

[27] Natl Ctr Child Hlth & Dev, Ctr Maternal Fetal Neonatal & Reprod Med, Tokyo, Japan

来源：

BMC PREGNANCY AND CHILDBIRTH | 2020年 / 20卷 / 01期

关键词：

Ambivalence; Genetic counseling; NIPT; Anticipatory anxiety; Content analysis; IN-VITRO FERTILIZATION; DECISION-MAKING; INFORMED CHOICE; ANXIETY; PREGNANCY; CONTEXT; SATISFACTION; EXPERIENCE; ATTACHMENT; TRIAL;

D O I：

10.1186/s12884-020-2763-z

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Background Women who receive negative results from non-invasive prenatal genetic testing (NIPT) may find that they later have mixed or ambivalent feelings, for example, feelings of accepting NIPT and regretting undergoing the test. This study aimed to investigate the factors generating ambivalent feelings among women who gave birth after having received negative results from NIPT. Methods A questionnaire was sent to women who received a negative NIPT result, and a contents analysis was conducted focusing on ambivalent expressions for those 1562 women who responded the questionnaire. The qualitative data gathered from the questionnaire were analyzed using the N-Vivo software package. Results Environmental factors, genetic counseling-related factors, and increased anticipatory anxiety, affected the feeling of ambivalence among pregnant women. Furthermore, pregnant women desired more information regarding the detailed prognosis for individuals with Down syndrome and living with them and/or termination, assuming the possibility that they were positive. Conclusions Three major interrelated factors affected the feeling of ambivalence in women. Highlighting and discussing such factors during genetic counseling may resolve some of these ambivalences, thereby enhancing the quality of decisions made by pregnant women.

引用

页数：9

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