Firing-Rate Response of a Neuron Receiving Excitatory and Inhibitory Synaptic Shot Noise

被引：69

作者：

Richardson, Magnus J. E. ^{[1
]}

Swarbrick, Rupert ^{[1
]}

机构：

[1] Univ Warwick, Warwick Syst Biol Ctr, Coventry CV4 7AL, W Midlands, England

来源：

PHYSICAL REVIEW LETTERS | 2010年 / 105卷 / 17期

关键词：

POPULATION; DYNAMICS; VOLTAGE;

D O I：

10.1103/PhysRevLett.105.178102

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The synaptic coupling between neurons in neocortical networks is sufficiently strong so that relatively few synchronous synaptic pulses are required to bring a neuron from rest to the spiking threshold. However, such finite-amplitude effects of fluctuating synaptic drive are missed in the standard diffusion approximation. Here exact solutions for the firing-rate response to modulated presynaptic rates are derived for a neuron receiving additive excitatory and inhibitory synaptic shot noise with exponential amplitude distributions. The shot-noise description of the neuronal response to synaptic dynamics is shown to be richer and qualitatively distinct from that predicted by the diffusion approximation. It is also demonstrated how the framework developed here can be generalized to multiplicative shot noise so as to better capture effects of the inhibitory reversal potential.

引用

页数：4

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