Post Infectious Bronchiolitis Obliterans in Children

被引：111

作者：

Fischer, Gilberto B. ^{[1
,2
]}

Sarria, Edgar E. ^{[1
,3
]}

Mattiello, Rita ^{[3
,4
]}

Mocelin, Helena T. ^{[1
]}

Castro-Rodriguez, Jose A. ^{[5
]}

机构：

[1] Hosp Crianca Santo Antonio, Serv Pneumol Pediat, Pediat Pulmonol Sect, BR-90035074 Porto Alegre, Brazil

[2] Univ Fed Ciencias Saude, Dept Paediat, Porto Alegre, RS, Brazil

[3] Indiana Univ, Herman Wells Ctr Pediat Res, Bloomington, IN 47405 USA

[4] Univ Fed Rio Grande do Sul, Pediat Postgrad Program, Porto Alegre, RS, Brazil

[5] Pontificia Univ Catolica Chile, Dept Paediat, Sch Med, Santiago, Chile

来源：

PAEDIATRIC RESPIRATORY REVIEWS | 2010年 / 11卷 / 04期

关键词：

Bronchiolitis obliterans; child; diagnosis; respiratory function tests; therapeutics; tomography; X-rays; LOWER RESPIRATORY-INFECTIONS; COMPUTED-TOMOGRAPHY; RISK-FACTORS; ADENOVIRUS; EPIDEMIOLOGY; INFLAMMATION; ADOLESCENTS; PNEUMONIA; EXERCISE;

D O I：

10.1016/j.prrv.2010.07.005

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Bronchiolitis Obliterans (BO) is an infrequent chronic and obstructive lung disease secondary to an insult to the terminal airway and its surroundings. In children, the most common presentation is the post-infectious variant, closely related to a severe viral infection in the first three years of life. However, the increase in the number of lung and bone-marrow transplants has also been followed by an increase in post-transplant BO. Post-transplant BO is progressive while post-infectious BO does not seem to be, but both forms share some common pathways that result in a characteristic histopathology of bronchiolar obliteration. This review covers up-to-date evidence on epidemiology, diagnosis, treatment and prognosis of post-infectious bronchiolitis obliterans, including areas of controversy that need to be addressed in future studies. (C) 2010 Published by Elsevier Ltd.

引用

页码：233 / 239

页数：7