共 26 条
Anabaena sensory rhodopsin is a light-driven unidirectional rotor
被引:64
作者:
Strambi, Angela
[1
,2
]
Durbeej, Bo
[1
]
Ferre, Nicolas
[3
]
Olivucci, Massimo
[1
,2
]
机构:
[1] Univ Siena, Dipartimento Chim, I-53100 Siena, Italy
[2] Bowling Green State Univ, Dept Chem, Bowling Green, OH 43403 USA
[3] Univ Aix Marseille, Fac Sci & Tech St Jerome, Lab Chim Provence, Equipe Chim Theor, F-13397 Marseille 20, France
来源:
关键词:
molecular motors;
molecular modeling;
photoreceptors;
stereochemistry;
chirality;
PERTURBATION-THEORY;
MOLECULAR MACHINES;
ENERGY-STORAGE;
STATE;
CHROMOPHORE;
NMR;
D O I:
10.1073/pnas.1015085107
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
The implementation of multiconfigurational quantum chemistry methods into a quantum-mechanics/molecular-mechanics protocol has allowed the construction of a realistic computer model for the sensory rhodopsin of the cyanobacterium Anabaena PCC 7120. The model, which reproduces the absorption spectra of both the all-trans and 13-cis forms of the protein and their associated K and L intermediates, is employed to investigate the light-driven steps of the photochromic cycle exhibited by the protein. It is found that the photoisomerizations of the all-trans and 13-cis retinal chromophores occur through unidirectional, counterclockwise 180 degrees rotations of the =C14-C15= moiety with respect to the Lys210-linked end of the chromophore axis. Thus, the sequential interconversions of the all-trans and 13-cis forms during a single photochromic cycle yield a complete (360 degrees) unidirectional rotation of the =C14-C15= moiety. This finding implies that Anabaena sensory rhodopsin is a biological realization of a light-driven molecular rotor.
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页码:21322 / 21326
页数:5
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