Limiting psychotropic medication prescription on discharge from psychiatric inpatient care: a possible suicide intervention?

被引:2
作者
Cleary, Eimear [1 ]
Kelleher, Cecily C. [2 ]
Lane, Abbie [1 ]
Malone, Kevin M. [1 ]
机构
[1] St Vincents Univ Hosp, UCD Sch Med, Dept Psychiat & Mental Hlth Res, Elm Pk, Dublin 4, Ireland
[2] St Vincents Univ Hosp, Univ Coll Dublin, Coll Hlth & Agr Sci, Dept Publ Hlth Physiotherapy & Sports Sci, Elm Pk, Dublin 4, Ireland
关键词
Psychotropic medication; suicide; suicide risk; DOSE EQUIVALENTS; RECOMMENDATIONS; TOXICITY; OVERDOSE; DRUGS; RATES;
D O I
10.1017/ipm.2019.25
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objectives Restricting access to lethal means is an effective suicide prevention strategy. However, there is little discussion in the literature about the potential contribution of prescribing practices on discharge from inpatient psychiatric care (which has been established as a high-risk period for suicide) to suicide deaths by overdose of prescribed medication. This study aimed to assess the quantity, toxicity and potential lethality of psychotropic medication being prescribed on discharge from psychiatric care to those with and without indices of suicidality. Methods Patient demographic, clinical and prescription data were collected from 50 randomly selected charts following discharge from inpatient psychiatric care. Psychotropic medications (dose x duration) on discharge were converted to their equivalent doses of neuroleptics, antidepressants and anxiolytics to rate toxicity and potential lethality, using the Maudsley Prescribing Guidelines. Mood stabilizing medications were also documented. Results 39% of prescriptions analysed contained toxic and potentially fatal doses of either neuroleptic or antidepressant equivalent medication. Conclusions Patient discharge from inpatient psychiatric care presents a golden opportunity to moderate access to potentially fatal psychotropic medication. Iatrogenic provision of lethal means for suicide during a period of increased risk and in a group at increased suicide risk may impact suicide prevention efforts and requires further in-depth research. Current prescribing practices may be a missed opportunity to intervene in this regard.
引用
收藏
页码:43 / 47
页数:5
相关论文
共 20 条
[1]   Lithium in the episode and suicide prophylaxis and in augmenting strategies in patients with unipolar depression [J].
Abou-Saleh, Mohammed T. ;
Mueller-Oerlinghausen, Bruno ;
Coppen, Alec J. .
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS, 2017, 5
[2]   Antipsychotic Dose Equivalents and Dose-Years: A Standardized Method for Comparing Exposure to Different Drugs [J].
Andreasen, Nancy C. ;
Pressler, Marcus ;
Nopoulos, Peg ;
Miller, Del ;
Ho, Beng-Choon .
BIOLOGICAL PSYCHIATRY, 2010, 67 (03) :255-262
[3]  
Appleby L., 2006, AVOIDABLE DEATHS 5 Y
[4]  
Ashton CH, 2002, Benzodiazepines: How They Work and How to Withdraw (The Ashton Manual)
[5]   Fatal toxicity of serotoninergic and other antidepressant drugs: analysis of United Kingdom mortality data [J].
Buckley, NA ;
McManus, PR .
BRITISH MEDICAL JOURNAL, 2002, 325 (7376) :1332-1333
[6]   Overdose profiles of new antipsychotic agents [J].
Capel, MM ;
Colbridge, MG ;
Henry, JA .
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2000, 3 (01) :51-54
[7]   Antisuicide properties of psychotropic drugs: A critical review [J].
Ernst, CL ;
Goldberg, JF .
HARVARD REVIEW OF PSYCHIATRY, 2004, 12 (01) :14-41
[8]   Safe and Effective Prescribing Practices at the Point of Discharge from an Inpatient Psychiatry Unit [J].
Fernandes, Virginia ;
Flak, Edred .
JOURNAL OF PSYCHIATRIC PRACTICE, 2012, 18 (01) :12-19
[9]   Toxicity of antidepressants: rates of suicide relative to prescribing and non-fatal overdose [J].
Hawton, Keith ;
Bergen, Helen ;
Simkin, Sue ;
Cooper, Jayne ;
Waters, Keith ;
Gunnell, David ;
Kapur, Navneet .
BRITISH JOURNAL OF PSYCHIATRY, 2010, 196 (05) :354-358
[10]   Dose equivalents of antidepressants: Evidence-based recommendations from randomized controlled trials [J].
Hayasaka, Yu ;
Purgato, Marianna ;
Magni, Laura R. ;
Ogawa, Yusuke ;
Takeshima, Nozomi ;
Cipriani, Andrea ;
Barbui, Corrado ;
Leucht, Stefan ;
Furukawa, Toshi A. .
JOURNAL OF AFFECTIVE DISORDERS, 2015, 180 :179-184