Synthesis of Allokainic Acid: A Review

被引:11
作者
Bhat, Chinmay [1 ]
Kumar, Amit [1 ]
机构
[1] Jain Univ, Ctr Nano & Mat Sci, Bangalore 562112, Karnataka, India
关键词
allokainic acid; kainic acid; kainoids; pyrrolidines; total synthesis; C-H INSERTION; CONFORMATIONALLY RESTRICTED ANALOGS; KUTZING CORSICAN-MOSS; ENE-TYPE REACTIONS; (+)-ALPHA-ALLOKAINIC ACID; FORMAL SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; AMINO-ACIDS; KAINIC ACID; STEREOSELECTIVE-SYNTHESIS;
D O I
10.1002/ajoc.201402250
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
This Focus Review discusses the synthesis of an important member of the kainoid family; allokainic acid. The members of the kainoid family have attracted worldwide attention since their first isolation in 1953 due to their vast and potential medicinal applications, especially in neuroscience. The review focuses on the synthesis of allokainic acid using different synthetic methods from its first synthesis to the most recent one, covering 1953-2014.
引用
收藏
页码:102 / 115
页数:14
相关论文
共 50 条
  • [41] An Update on the Synthesis of β-Lactams
    Teresa Aranda, M.
    Perez-Faginas, Paula
    Gonzalez-Muniz, Rosario
    CURRENT ORGANIC SYNTHESIS, 2009, 6 (03) : 325 - 341
  • [42] Recent advances in asymmetric synthesis of pipecolic acid and derivatives - Review article
    Kadouri-Puchot, C
    Comesse, S
    AMINO ACIDS, 2005, 29 (02) : 101 - 130
  • [43] Synthesis, Structure and Application of α,β-Dehydro-α-aminophosphonic and α,β Dehydro-α-aminophosphinic Acid Derivatives
    Kuznik, Anna
    Mazurkiewicz, Roman
    Kunik, Nikodem
    CURRENT ORGANIC SYNTHESIS, 2013, 10 (03) : 411 - 424
  • [44] Enantioselective Total Synthesis of (-)-Martinellic Acid
    Pappoppula, Mukesh
    Aponick, Aaron
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (52) : 15827 - 15830
  • [45] Palladium-Mediated Annulation of Vinyl Aziridines with Michael Acceptors: Stereocontrolled Synthesis of Substituted Pyrrolidines and Its Application in a Formal Synthesis of (-)-α-Kainic Acid
    Lowe, Martin A.
    Ostovar, Mehrnoosh
    Ferrini, Serena
    Chen, C. Chun
    Lawrence, Paul G.
    Fontana, Francesco
    Calabrese, Andrew A.
    Aggarwal, Varinder K.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (28) : 6370 - 6374
  • [46] A Concise Total Synthesis of (-)-Berkelic Acid
    Cheng, Hong-Gang
    Yang, Zhenjie
    Chen, Ruiming
    Cao, Liming
    Tong, Wen-Yan
    Wei, Qiang
    Wang, Qingqing
    Wu, Chenggui
    Qu, Shuanglin
    Zhou, Qianghui
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 60 (10) : 5141 - 5146
  • [47] A Nitro Sugar-Mediated Stereocontrolled Synthesis of β2-Amino Acids: Synthesis of a Polyhydroxylated trans-2-Amino-cyclohexanecarboxylic Acid
    Otero, Jose M.
    Fernandez, Fernando
    Estevez, Juan C.
    Nash, Robert
    Estevez, Ramon J.
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2012, 2012 (15) : 2969 - 2979
  • [48] Efficient Synthesis of (R)- and (S)-α-(Hydroxymethyl)pyroglutamic Acid Esters from L-Proline
    Shinada, Tetsuro
    Yoshida, Hiroki
    Ohfune, Yasufumi
    SYNTHESIS-STUTTGART, 2009, (22): : 3751 - 3756
  • [49] Approaches to the Total Synthesis of Conduramines: A Review
    Bharathkumar, Hanumantharayappa
    Krishna, Jattuboyina Siva
    Surender, Banothu
    Batchu, Venkateswara Rao
    SYNOPEN, 2022, 06 (04): : 238 - 257
  • [50] Stereospecific Synthesis of β3-Amino Acid Derivatives from Propargylic Alcohols: Efficient Solution-Phase Synthesis of Oligopeptides without Coupling Agents
    Temperini, Andrea
    Terlizzi, Raffaella
    Testaferri, Lorenzo
    Tiecco, Marcello
    CHEMISTRY-A EUROPEAN JOURNAL, 2009, 15 (32) : 7883 - 7895