Tricyclic 2′-C-Modified Nucleosides as Potential Anti-HCV Therapeutics

被引：19

作者：

Wauchope, Orrette R. ^{[2
]}

Tomney, Matthew J. ^{[2
]}

Pepper, Joseph L. ^{[2
]}

Korba, Brent E. ^{[1
]}

Seley-Radtke, Katherine L. ^{[1
]}

机构：

[1] Georgetown Univ, Med Ctr, Dept Microbiol & Immunol, Washington, DC 20057 USA

[2] Univ Maryland, Dept Chem & Biochem, Baltimore, MD 21250 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 20期

关键词：

C VIRUS-REPLICATION; INHIBITORS; DESIGN;

D O I：

10.1021/ol101482h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Promising biological activity in a number of therapeutic areas has been reported for both tricyclic nucleosides and 2'-modified nucleosides. In particular, disubstitution at the C-2' position of nucleosides has resulted in significant activity against the hepatitis C virus (HCV). Combining this with the observation that tricyclic nucleosides developed in our laboratory have been shown to inhibit the RNA-dependent RNA polymerase NS5B led to the design of a series of 2'-modified tricyclic nucleosides. Details of the synthesis, structural characterization, and preliminary biological results are reported.

引用

页码：4466 / 4469

页数：4