Tricyclic 2′-C-Modified Nucleosides as Potential Anti-HCV Therapeutics

被引：19
作者：
Wauchope, Orrette R. [2 ]
Tomney, Matthew J. [2 ]
Pepper, Joseph L. [2 ]
Korba, Brent E. [1 ]
Seley-Radtke, Katherine L. [1 ]
机构：
[1] Georgetown Univ, Med Ctr, Dept Microbiol & Immunol, Washington, DC 20057 USA
[2] Univ Maryland, Dept Chem & Biochem, Baltimore, MD 21250 USA
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 20期
关键词：
C VIRUS-REPLICATION; INHIBITORS; DESIGN;
D O I：
10.1021/ol101482h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Promising biological activity in a number of therapeutic areas has been reported for both tricyclic nucleosides and 2'-modified nucleosides. In particular, disubstitution at the C-2' position of nucleosides has resulted in significant activity against the hepatitis C virus (HCV). Combining this with the observation that tricyclic nucleosides developed in our laboratory have been shown to inhibit the RNA-dependent RNA polymerase NS5B led to the design of a series of 2'-modified tricyclic nucleosides. Details of the synthesis, structural characterization, and preliminary biological results are reported.
引用
收藏
页码：4466 / 4469
页数：4
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