Oncolytic herpes simplex virus tumor targeting and neutralization escape by engineering viral envelope glycoproteins

被引：22

作者：

Liu, Xiao-Qin ^{[1
,2
,3
,4
]}

Xin, Hong-Yi ^{[5
]}

Lyu, Yan-Ning ^{[6
]}

Ma, Zhao-Wu ^{[1
,2
,3
]}

Peng, Xiao-Chun ^{[1
,2
,7
]}

Xiang, Ying ^{[1
,2
,3
]}

Wang, Ying-Ying ^{[1
,2
,3
]}

Wu, Zi-Jun ^{[1
,2
,3
,4
]}

Cheng, Jun-Ting ^{[1
,2
,3
]}

Ji, Jia-Fu ^{[8
]}

Zhong, Ji-Xin ^{[9
]}

Ren, Bo-Xu ^{[1
,4
]}

Wang, Xian-Wang ^{[1
,2
,10
]}

Xin, Hong-Wu ^{[1
,2
,3
]}

机构：

[1] Yangtze Univ, Sch Clin Med 2, Fac Med, 1 Nanhuan Rd, Jingzhou 434023, Hubei, Peoples R China

[2] Yangtze Univ, Sch Basic Med, Ctr Mol Med, Lab Oncol,Fac Med, 1 Nanhuan Rd, Jingzhou 434023, Hubei, Peoples R China

[3] Yangtze Univ, Sch Basic Med, Dept Biochem & Mol Biol, Fac Med, Jingzhou, Hubei, Peoples R China

[4] Yangtze Univ, Dept Nursing & Med Imaging Technol, Jingzhou, Hubei, Peoples R China

[5] Star Array Pte Ltd, JTC Medtech Hub, Singapore, Singapore

[6] Beijing Ctr Dis Prevent & Control, Inst Infect Dis & Endem Dis Prevent & Control, Beijing, Peoples R China

[7] Yangtze Univ, Sch Basic Med, Dept Pathophysiol, Fac Med, Jingzhou, Hubei, Peoples R China

[8] Peking Univ, Dept Gastrointestinal Surg, Key Lab Carcinogenesis & Translat Res, Minist Educ,Canc Hosp & Inst, Beijing, Peoples R China

[9] Case Western Reserve Univ, Cardiovasc Res Inst, Cleveland, OH 44106 USA

[10] Yangtze Univ, Sch Basic Med, Dept Lab Med, Fac Med, Jingzhou, Hubei, Peoples R China

来源：

DRUG DELIVERY | 2018年 / 25卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Oncolytic virotherapy; herpes simplex virus; envelope glycoprotein; tumor targeting; immune escape; neutralization antibody; 3-O-SULFATED HEPARAN-SULFATE; RECEPTOR-RELATED PROTEIN-1; RETAINING CANCER-CELLS; 1 GB CYTODOMAIN; MONOCLONAL-ANTIBODY; POLIOVIRUS RECEPTOR; PHASE-I; GH-GL; RELATIVELY RESISTANT; ANTIGENIC ANALYSIS;

D O I：

10.1080/10717544.2018.1534895

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oncolytic herpes simplex viruses (oHSVs) have been approved for clinical usage and become more and more popular for tumor virotherapy. However, there are still many issues for the oHSVs used in clinics and clinical trials. The main issues are the limited anti-tumor effects, intratumor injection, and some side effects. To overcome such challenges, here we review the genetic engineering of the envelope glycoproteins for oHSVs to target tumors specifically, and at the same time we summarize the many neutralization antibodies against the envelope glycoproteins and align the neutralization epitopes with functional domains of the respective glycoproteins for future identification of new functions of the glycoproteins and future engineering of the epitopes to escape from host neutralization.

引用

页码：1950 / 1962

页数：13

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