The In Situ Sulfidation of Cu2O by Endogenous H2S for Colon Cancer Theranostics

被引：180
作者：
An, Lu [1 ,2 ]
Wang, Xiaodong [1 ,2 ]
Rui, Xichuan [1 ,2 ]
Lin, Jiaomin [1 ,2 ]
Yang, Hong [1 ,2 ]
Tian, Qiwei [1 ,2 ]
Tao, Cheng [1 ,2 ]
Yang, Shiping [1 ,2 ]
机构：
[1] Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Minist Educ, Key Lab Resource Chem, Shanghai 200234, Peoples R China
[2] Shanghai Normal Univ, Shanghai Municipal Educ Comm Key Lab Mol Imaging, Shanghai 200234, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 48期
基金：
中国国家自然科学基金;
关键词：
colon cancer; cuprous oxide; endogenous H2S; in situ reactions; theranostics; HYDROGEN-SULFIDE; PROBES; CELLS;
D O I：
10.1002/anie.201810082
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Expression of a high concentration of H2S is closely related to the formation of colon cancer tumors. However, only a few H2S-triggered theranostics agents for colon cancer have been reported to date. Now, a turn-on theranostics agent was developed by utilizing the in situ reaction of Cu2O and endogenous H2S at colon tumor sites. Based on in vitro and in vivo experiments, excellent photoacoustic imaging and photothermal therapy were both confirmed by this in situ reaction-activated colon cancer theranostics method. This work established a simple and efficient strategy for both diagnosis and treatment of colon cancer with a novel trigger mechanism, which provides a new route for colon cancer theranostics based on the in situ reactions at the tumor sites.
引用
收藏
页码：15782 / 15786
页数：5
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