Taste masking of Etoricoxib by using ion-exchange resin

被引:22
作者
Patra, Sradhanjali [1 ]
Samantaray, Rakesh [1 ]
Pattnaik, Saswat [1 ]
Barik, B. B. [1 ]
机构
[1] Utkal Univ, Univ Dept Pharmaceut Sci, Bhubaneswar 4, Orissa, India
关键词
Etoricoxib; taste masking; Indion; 204; resin; drug resin complex; drug-loading efficiency;
D O I
10.3109/10837450903322787
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The present study was carried out in order to mask the bitter taste of the Etoricoxib by complexation with cation-exchange resin, Indion 204. The drug resin complexes (DRC) were prepared by batch process and efficient drug loading was obtained by using inactivated form of resin in the drug-resin ratio 1:3.3 with 30 min swelling time of resin in 25 mL of water with 5 min stirring time. Drug-resin complexes were characterized for dissolution studies and spectral studies. Drug release from drug-resin complex in salivary pH was insufficient to impart bitter taste. Volunteers rated the drug resin complex as tasteless and agreeable.
引用
收藏
页码:511 / 517
页数:7
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