Taste masking of Etoricoxib by using ion-exchange resin

被引：23

作者：

Patra, Sradhanjali ^{[1
]}

Samantaray, Rakesh ^{[1
]}

Pattnaik, Saswat ^{[1
]}

Barik, B. B. ^{[1
]}

机构：

[1] Utkal Univ, Univ Dept Pharmaceut Sci, Bhubaneswar 4, Orissa, India

来源：

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY | 2010年 / 15卷 / 05期

关键词：

Etoricoxib; taste masking; Indion; 204; resin; drug resin complex; drug-loading efficiency;

D O I：

10.3109/10837450903322787

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study was carried out in order to mask the bitter taste of the Etoricoxib by complexation with cation-exchange resin, Indion 204. The drug resin complexes (DRC) were prepared by batch process and efficient drug loading was obtained by using inactivated form of resin in the drug-resin ratio 1:3.3 with 30 min swelling time of resin in 25 mL of water with 5 min stirring time. Drug-resin complexes were characterized for dissolution studies and spectral studies. Drug release from drug-resin complex in salivary pH was insufficient to impart bitter taste. Volunteers rated the drug resin complex as tasteless and agreeable.

引用

页码：511 / 517

页数：7

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