Is the EFNB2 locus associated with schizophrenia? Single nucleotide polymorphisms and haplotypes analysis

被引：17

作者：

Zhang, Rui ^{[1
]}

Zhong, Nan-Nan ^{[1
]}

Liu, Mao-Gang ^{[2
]}

Yan, Han ^{[2
]}

Qiu, Chuan ^{[2
]}

Han, Yan ^{[1
]}

Wang, Wei ^{[1
]}

Hou, Wei-Kun ^{[1
]}

Liu, Yue ^{[1
]}

Gao, Cheng-Ge ^{[3
]}

Guo, Ting-Wei ^{[1
,4
]}

Lu, She-Min ^{[1
]}

Deng, Hong-Wen ^{[2
]}

Ma, Jie ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Dept Genet & Mol Biol, Sch Med, Xian 710061, Shaanxi, Peoples R China

[2] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Xian 710061, Shaanxi, Peoples R China

[3] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Xian 710061, Shaanxi, Peoples R China

[4] NIDDK, NIH, Phoenix, AZ USA

来源：

PSYCHIATRY RESEARCH | 2010年 / 180卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Schizophrenia; EFNB2; SNP; Haplotype; Association; NMDA; AMINO-ACID OXIDASE; TRANSMISSION DISEQUILIBRIUM; G72/G30; POLYMORPHISMS; GENE-EXPRESSION; CANDIDATE GENES; NO ASSOCIATION; DAOA; LINKAGE; G72; SUSCEPTIBILITY;

D O I：

10.1016/j.psychres.2010.04.037

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Recently evidence of linkage of schizophrenia to chromosome 13q22-q34 has been demonstrated in multiple studies Based on structure and function EFNB2 may be considered as a compelling candidate gene for schizophrenia on chromosome 13q33 We genotyped three single-nucleotide polymorphisms (SNPs rs9520087 rs11069646 and rs8000078) in this region in 846 Han Chinese subjects (477 cases and 369 controls) Significant association between an allele of marker rs9520087 and schizophrenia was found Furthermore since no ID was observed in the three SNPs linkage disequilibrium estimation all three SNPs were used in multiple SNPs haplotype analysis and a strongly significant difference was found for the common haplotype TTC Overall our findings indicate that EFNB2 gene may be a candidate susceptibility gene for schizophrenia in the Han Chinese population and also provide further support for the potential importance of the NMDA receptor pathway in the etiology of schizophrenia (C) 2010 Elsevier Ireland Ltd All rights reserved

引用

页码：5 / 9

页数：5

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