N-Heterocyclic Carbene Catalyzed Vinylogous Aldol Reaction of 2-(Trimethylsilyloxy) furan and Aldehydes

被引：26
|
作者：
Du, Guang-Fen [1 ]
He, Lin [1 ]
Gu, Cheng-Zhi [1 ]
Dai, Bin [1 ]
机构：
[1] Shi He Zi Univ, Sch Chem & Chem Engn, Xin Jiang 832000, Peoples R China
来源：
SYNLETT | 2010年 / 16期
关键词：
N-heterocyclic carbenes; vinylogous aldol reaction; butenolides; 2-(trimethylsilyloxy)furan; aldehyde; HIGHLY ENANTIOSELECTIVE SYNTHESIS; NUCLEOPHILIC CARBENES; EFFICIENT CATALYST; CONJUGATE UMPOLUNG; 4+2 CYCLOADDITION; STETTER REACTION; KETENES; CARBON; CYANOSILYLATION; ACYLATION;
D O I：
10.1055/s-0030-1258551
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A N-Heterocyclic carbenes (NHC) catalyzed vinylogous aldol reaction between 2-(trimethylsilyloxy) furan and aldehydes has been developed, providing gamma-substituted butenolides in high yields with good diastereoselectivities. Furthermore, the catalyst loading can be reduced to 1 mol%.
引用
收藏
页码：2513 / 2517
页数：5
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