N-Heterocyclic Carbene Catalyzed Vinylogous Aldol Reaction of 2-(Trimethylsilyloxy) furan and Aldehydes

被引：26

作者：

Du, Guang-Fen ^{[1
]}

He, Lin ^{[1
]}

Gu, Cheng-Zhi ^{[1
]}

Dai, Bin ^{[1
]}

机构：

[1] Shi He Zi Univ, Sch Chem & Chem Engn, Xin Jiang 832000, Peoples R China

来源：

SYNLETT | 2010年 / 16期

关键词：

N-heterocyclic carbenes; vinylogous aldol reaction; butenolides; 2-(trimethylsilyloxy)furan; aldehyde; HIGHLY ENANTIOSELECTIVE SYNTHESIS; NUCLEOPHILIC CARBENES; EFFICIENT CATALYST; CONJUGATE UMPOLUNG; 4+2 CYCLOADDITION; STETTER REACTION; KETENES; CARBON; CYANOSILYLATION; ACYLATION;

D O I：

10.1055/s-0030-1258551

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A N-Heterocyclic carbenes (NHC) catalyzed vinylogous aldol reaction between 2-(trimethylsilyloxy) furan and aldehydes has been developed, providing gamma-substituted butenolides in high yields with good diastereoselectivities. Furthermore, the catalyst loading can be reduced to 1 mol%.

引用

页码：2513 / 2517

页数：5