On the potential for molecular imaging with Cerenkov luminescence

被引：59
作者：
Lewis, Matthew A. [1 ]
Kodibagkar, Vikram D. [1 ]
Oez, Orhan K. [1 ]
Mason, Ralph P. [1 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Radiol, Dallas, TX 75390 USA
来源：
OPTICS LETTERS | 2010年 / 35卷 / 23期
基金：
美国国家卫生研究院;
关键词：
ABSORPTION; GADOLINIUM;
D O I：
10.1364/OL.35.003889
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Recent observation of optical luminescence due to beta decay from suitable radiotracers has led to the possible development of new preclinical optical imaging methods. The generation of photons that can be detected using instrumentation optimized for bioluminescence imaging has been putatively associated with the Cerenkov effect. We describe the simultaneous utilization of fluorescence reporters to convert Cerenkov luminescence to longer wavelengths for better tissue penetration and also for modulating the luminescence spectrum for potential molecular imaging strategies. (C) 2010 Optical Society of America
引用
收藏
页码：3889 / 3891
页数：3
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