Genetic disruption of PPARδ decreases the tumorigenicity of human colon cancer cells

被引：217
作者：
Park, BH
Vogelstein, B
Kinzler, KW
机构：
[1] Johns Hopkins Oncol Ctr, Baltimore, MD 21231 USA
[2] Howard Hughes Med Inst, Baltimore, MD 21231 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2001年 / 98卷 / 05期
关键词：
D O I：
10.1073/pnas.051630998
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that have been implicated in a variety of biologic processes. The PPAR delta isotype was recently proposed as a downstream target of the adenomatous polyposis coli (APC)/beta catenin pathway in colorectal carcinogenesis. To evaluate its role in tumorigenesis, a PPAR delta null cell line was created by targeted homologous recombination. When inoculated as xenografts in nude mice, PPAR delta -/- cells exhibited a decreased ability to form tumors compared with PPAR delta +/- and wild-type controls. These data suggest that suppression of PPAR delta expression contributes to the growth-inhibitory effects of the APC tumor suppressor.
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页码：2598 / 2603
页数：6
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