The effects of a DTNBP1 gene variant on attention networks: an fMRI study

被引：12

作者：

Thimm, Markus ^{[1
]}

Krug, Axel ^{[2
]}

Kellermann, Thilo ^{[1
]}

Markov, Valentin ^{[1
]}

Krach, Soeren ^{[3
,4
]}

Jansen, Andreas ^{[3
]}

Zerres, Klaus ^{[5
]}

Eggermann, Thomas ^{[5
]}

Stoecker, Tony ^{[6
]}

Shah, N. Jon ^{[6
]}

Noethen, Markus M. ^{[7
,8
]}

Rietschel, Marcella ^{[9
]}

Kircher, Tilo ^{[2
]}

机构：

[1] Rhein Westfal TH Aachen, Dept Psychiat & Psychotherapy, D-52074 Aachen, Germany

[2] Univ Marburg, Dept Psychiat & Psychotherapy, D-35039 Marburg, Germany

[3] Univ Marburg, Sect Brain Imaging, D-35039 Marburg, Germany

[4] Univ Marburg, Dept Neurol, D-35039 Marburg, Germany

[5] Rhein Westfal TH Aachen, Inst Human Genet, D-52074 Aachen, Germany

[6] Forschungszentrum Julich, Inst Neurosci & Med 4, D-52425 Julich, Germany

[7] Univ Bonn, Inst Human Genet, D-53111 Bonn, Germany

[8] Univ Bonn, Dept Genome, Life & Brain Ctr, D-53127 Bonn, Germany

[9] Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, D-68159 Mannheim, Germany

来源：

BEHAVIORAL AND BRAIN FUNCTIONS | 2010年 / 6卷

关键词：

ANTERIOR CINGULATE CORTEX; DYSBINDIN GENE; BRAIN ACTIVATION; SCHIZOPHRENIA-PATIENTS; 1ST-DEGREE RELATIVES; SUSTAINED ATTENTION; SUSCEPTIBILITY GENE; COGNITIVE FUNCTIONS; MOLECULAR-GENETICS; PERFORMANCE;

D O I：

10.1186/1744-9081-6-54

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Background: Attention deficits belong to the main cognitive symptoms of schizophrenia and come along with altered neural activity in previously described cerebral networks. Given the high heritability of schizophrenia the question arises if impaired function of these networks is modulated by susceptibility genes and detectable in healthy risk allele carriers. Methods: The present event-related fMRI study investigated the effect of the single nucleotide polymorphism (SNP) rs1018381 of the DTNBP1 (dystrobrevin-binding protein 1) gene on brain activity in 80 subjects while performing the attention network test (ANT). In this reaction time task three domains of attention are probed simultaneously: alerting, orienting and executive control of attention. Results: Risk allele carriers showed impaired performance in the executive control condition associated with reduced neural activity in the left superior frontal gyrus [Brodmann area (BA) 9]. Risk allele carriers did not show alterations in the alerting and orienting networks. Conclusions: BA 9 is a key region of schizophrenia pathology and belongs to a network that has been shown previously to be involved in impaired executive control mechanisms in schizophrenia. Our results identified the impact of DTNBP1 on the development of a specific attention deficit via modulation of a left prefrontal network.

引用

页数：9