Synthesis of (E)- and (Z)-fluoro-olefin analogues of potent dipeptidyl peptidase IV inhibitors

被引：34
|
作者：
Van der Veken, P [1 ]
Kertèsz, I [1 ]
Senten, K [1 ]
Haemers, A [1 ]
Augustyns, K [1 ]
机构：
[1] Univ Instelling Antwerp, Dept Med Chem, B-2610 Antwerp, Belgium
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 33期
关键词：
D O I：
10.1016/S0040-4039(03)01542-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
(E)- and (Z)-fluoro-olefin analogues of potent dipeptidyl peptidase IV inhibitors were synthesized. A WadsworthHorner-Eminons reaction, followed by amide formation and reduction of the amide were used for the construction of the alpha-fluoro-alpha,beta-unsaturated amine functionality. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6231 / 6234
页数：4
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