Synthesis of (E)- and (Z)-fluoro-olefin analogues of potent dipeptidyl peptidase IV inhibitors

被引：34

作者：

Van der Veken, P ^{[1
]}

Kertèsz, I ^{[1
]}

Senten, K ^{[1
]}

Haemers, A ^{[1
]}

Augustyns, K ^{[1
]}

机构：

[1] Univ Instelling Antwerp, Dept Med Chem, B-2610 Antwerp, Belgium

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(03)01542-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(E)- and (Z)-fluoro-olefin analogues of potent dipeptidyl peptidase IV inhibitors were synthesized. A WadsworthHorner-Eminons reaction, followed by amide formation and reduction of the amide were used for the construction of the alpha-fluoro-alpha,beta-unsaturated amine functionality. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：6231 / 6234

页数：4

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