Circulating maternal testosterone concentrations at 18 weeks of gestation predict circulating levels of antimullerian hormone in adolescence: a prospective cohort study

被引：36
作者：
Hart, Roger [1 ]
Sloboda, Deborah M. [2 ,3 ]
Doherty, Dorota A. [1 ,4 ]
Norman, Robert J. [5 ]
Atkinson, Helen C. [1 ]
Newnham, John P. [1 ,4 ]
Dickinson, Jan E. [1 ]
Hickey, Martha [1 ]
机构：
[1] Univ Western Australia, Sch Womens & Infants Hlth, Perth, WA 6009, Australia
[2] Univ Auckland, Liggins Inst, Auckland 1, New Zealand
[3] Natl Res Ctr Growth & Dev, Auckland, New Zealand
[4] King Edward Mem Hosp Women, Women & Infants Res Fdn, Perth, WA, Australia
[5] Univ Adelaide, Res Ctr Reprod Hlth, Robinson Inst, Adelaide, SA, Australia
来源：
FERTILITY AND STERILITY | 2010年 / 94卷 / 04期
基金：
英国医学研究理事会;
关键词：
Adolescence; AMH; PCO; PCOS; Raine cohort; ANDROGENS; WOMEN;
D O I：
10.1016/j.fertnstert.2009.12.060
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
This prospective study was established to determine the impact of maternal circulating androgen levels during normal pregnancy on ovarian function, as determined by early follicular phase antimullerian hormone (AMH) levels, inhibin B levels, and antral follicle count (AFC) in 244 female offspring in adolescence. Maternal circulating total testosterone levels at 18 weeks' gestation were statistically significantly correlated with early follicular-phase circulating AMH levels in female adolescent offspring, but no other statistically significant correlations were determined among the maternal androgens at 18 or 34 weeks of gestation and the markers of adolescent ovarian function. (Fertil Steril (R) 2010;94:1544-7. (C) 2010 by American Society for Reproductive Medicine.)
引用
收藏
页码：1544 / 1547
页数：4
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