Chemoselective reduction of ketones: trifluoromethylketones versus methylketones

被引：22

作者：

Sasaki, S

Yamauchi, T

Kubo, H

Kanai, M

Ishii, A

Higashiyama, K ^{[1
]}

机构：

[1] Hoshi Univ, Inst Med Chem, Tokyo 1428501, Japan

[2] Cent Glass Co Ltd, Chem Res Ctr, Kawagoe, Saitama 3501151, Japan

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 09期

关键词：

chemoselective reduction; trifluoromethylketones; methylketones; diethylzinc;

D O I：

10.1016/j.tetlet.2005.01.013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of an equimolar mixture of trifluoromethylketones (TFMKs) and methylketones (MKs) with Et2Zn resulted in selective reduction of the TFMKs in good yield. In contrast, treatment of an equimolar mixture of TFMKs and MKs with NaBH4 in the presence of CeCl3 in EtOH/H2O (10:1) at -10degreesC reduced only the MKs. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1497 / 1500

页数：4

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