Efficient Synthesis of 2-Fluoromethylated Quinolines via Copper-Catalyzed Alkynylation and Cyclization of Fluorinated Imidoyl Iodides

被引：39

作者：

Li, Shan ^{[1
]}

Yuan, Yafen ^{[1
]}

Zhu, Jiangtao ^{[1
]}

Xie, Haibo ^{[1
]}

Chen, Zixian ^{[1
,2
]}

Wu, Yongming ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

[2] Huazhong Univ Sci & Technol, Dept Chem, Wuhan 430074, Hubei, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 10期

基金：

美国国家科学基金会;

关键词：

copper; coupling reactions; cyclization; fluorinated alkynylimines; fluorinated quinolines; REGIOSPECIFIC SYNTHESIS; CHLORIDES; BOND;

D O I：

10.1002/adsc.201000180

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

2-Fluoromethylated quinolines were synthesized through the reaction of N-aryl-fluorinated imidoyl iodides with terminal alkynes in good yields by the catalysis of copper(I) iodide (CuI) alone.

引用

页码：1582 / 1586

页数：5

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