Cooperation among cancer cells: applying game theory to cancer

被引：124

作者：

Archetti, Marco ^{[1
,2
]}

Pienta, Kenneth J. ^{[3
]}

机构：

[1] Penn State Univ, Dept Biol, State Coll, PA 16801 USA

[2] Univ East Anglia, Sch Biol Sci, Norwich, Norfolk, England

[3] Johns Hopkins Sch Med, Brady Urol Inst, Baltimore, MD USA

来源：

NATURE REVIEWS CANCER | 2019年 / 19卷 / 02期

关键词：

GROWTH-FACTOR PRODUCTION; PUBLIC-GOODS; EVOLUTIONARY-GAME; TUMOR-GROWTH; MICROENVIRONMENTAL REGULATION; VOLUNTEERS DILEMMA; NATURAL-SELECTION; CLONAL EVOLUTION; DRUG-RESISTANCE; SOCIAL DILEMMAS;

D O I：

10.1038/s41568-018-0083-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cell cooperation promotes many of the hallmarks of cancer via the secretion of diffusible factors that can affect cancer cells or stromal cells in the tumour microenvironment. This cooperation cannot be explained simply as the collective action of cells for the benefit of the tumour because non-cooperative subclones can constantly invade and free-ride on the diffusible factors produced by the cooperative cells. A full understanding of cooperation among the cells of a tumour requires methods and concepts from evolutionary game theory, which has been used successfully in other areas of biology to understand similar problems but has been underutilized in cancer research. Game theory can provide insights into the stability of cooperation among cells in a tumour and into the design of potentially evolution-proof therapies that disrupt this cooperation.

引用

页码：110 / 117

页数：8

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