Method for the Direct Enantioselective Synthesis of Chiral Primary α-Amino Ketones by Catalytic α-Amination

被引：29

作者：

Han, Yixin ^{[1
]}

Corey, E. J. ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 01期

关键词：

STEREOSPECIFIC SYNTHESIS; N-H; KETAMINE; AZIRIDINES;

D O I：

10.1021/acs.orglett.8b03733

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A useful catalytic enantioselective approach has been developed for the synthesis of chiral ketamine analogs using Rh(II)-catalyzed amination of triisopropylsilyl enol ethers to form alpha-amino ketones with O-(4-nitrophenyl)hydroxylamine as nitrogen donor in 81-91% ee.

引用

页码：283 / 286

页数：4

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