Usefulness of three SOS-response tests for genotoxicity detection

被引：0
作者：
Flegrova, Zuzana [1 ]
Skarek, Michal [1 ]
Bartos, Tomas [1 ]
Cupr, Pavel [1 ]
Holoubek, Ivan [1 ]
机构：
[1] Masaryk Univ, RECETOX, Fac Sci, Brno 62500, Czech Republic
来源：
FRESENIUS ENVIRONMENTAL BULLETIN | 2007年 / 16卷 / 11A期
关键词：
genotoxicity; recA; SOS response; DPD2794; SOS chromotest; umuC test;
D O I：
暂无
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The RecA test, a luminescence SOS reporter test, and two well-known SOS reporter assays, umuC test and SOS chromotest, were compared. The main point of this study was to indicate the sensitivity of these tests. This was on the basis of comparison of effects on standard mutagens and environmental samples. The results with the selected chemicals showed that the RecA test was less sensitive in a qualitative way, in comparison to the umuC test. However, its responses were quite comparable with the SOS chromotest. Results suggest that for our choice of environmental samples and chemical standards the umuC test is optimal for genotoxicity detection, in comparison to RecA test and SOS chromotest.
引用
收藏
页码：1369 / 1376
页数：8
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