Six new ergosterols from the marine-derived fungus Rhizopus sp.

被引：52

作者：

Wang, Fazuo ^{[1
]}

Fang, Yuchun ^{[1
]}

Zhang, Min ^{[1
]}

Lin, Aiqun ^{[1
]}

Zhu, Anjiao ^{[1
]}

Gu, Qianqun ^{[1
]}

Zhu, Weiming ^{[1
]}

机构：

[1] Ocean Univ China, Inst Marine Drugs & Food, Key Lab Marine Drugs, Chinese Minist Educ, Qingdao 266003, Peoples R China

来源：

STEROIDS | 2008年 / 73卷 / 01期

关键词：

sterols; marine-derived; fungi; structure identification; cytotoxicity;

D O I：

10.1016/j.steroids.2007.08.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six new ergosterols, including 3 beta-hydroxyl-(22E, 24R)-ergosta-5,8,22-trien-7,15-dione (1), 3 beta-hydroxyl-(22E, 24R) -ergosta-5,8,14,22-tetraen-7-one (2), 3 beta,15 beta-dihydroxyl-(22E, 24R)-ergosta-5,8(14),22-trien-7-one (3), 3 beta,15 alpha-dihydroxyl-(22E, 24R)-ergosta-5,8(14),22-trien-7-one (4), 3 beta-hydroxyl-(22E, 24R)-ergosta-5,8(14),22-trien-7,15-dione (5), and 5 alpha,8 alpha-epidioxy-23,24(R)-dimethylcholesta-6,9(11),22-trien-3 beta-ol (6), have been isolated from the marine-derived fungus Rhizopus sp., along with four known ones (7-10). The structures of the new compounds were determined on the basis of extensive spectroscopic data. All compounds were evaluated for their cytotoxic activities on P388, A549, HL-60, and BEL-7420 cell lines by the MTT and SRB methods. (C) 2007 Published by Elsevier Inc.

引用

页码：19 / 26

页数：8

共 20 条

[1] DETERMINATION OF ABSOLUTE-CONFIGURATION AT C-20 AND C-24 OF ERGOSTEROL IN ASCOMYCETES AND BASIDIOMYCETES BY PROTON MAGNETIC-RESONANCE SPECTROSCOPY [J].