Pd/C-catalyzed alkynylation of β-chloroacroleins

被引：17

作者：

Bera, Rabin ^{[1
]}

Swamy, Nalivela Kumara ^{[2
]}

Dhananjaya, G. ^{[1
]}

Babu, J. Moses ^{[2
]}

Kumar, P. Rajender ^{[1
]}

Mukkanti, K. ^{[3
]}

Pal, Manojit ^{[2
]}

机构：

[1] Dr Reddys Labs Ltd, Custom Pharmaceut Serv, Hyderabad 500049, Andhra Pradesh, India

[2] Dr Reddys Labs Ltd, Discovery Res, Hyderabad 500049, Andhra Pradesh, India

[3] JNT Univ, Div Chem, Inst Sci & Technol, Hyderabad 500072, Andhra Pradesh, India

来源：

TETRAHEDRON | 2007年 / 63卷 / 52期

关键词：

D O I：

10.1016/j.tet.2007.10.013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first Pd/C-mediated Sonogashira coupling of beta-chloroacroleins with terminal alkynes is described here. Pd/C-CuI-PPh3 was found to be an efficient catalyst system for this coupling reaction. Using this economic and general process a variety of 4-alkynyl-2H-chromene-3-carbaldehydes and 5-alkynyl-2,3-dihydro benzo[b]oxepine-4-carbaldehydes were prepared in good yields. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：13018 / 13023

页数：6

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