Ultra-short metformin pretreatment for clomiphene citrate-resistant polycystic ovary syndrome

被引：36
作者：
Hwu, YM
Lin, SY
Huang, WY
Lin, MH
Lee, RKK
机构：
[1] Mackay Mem Hosp, Dept Obstet & Gynecol, Taipei, Taiwan
[2] Mackay Med Nursing & Management Coll, Taipei, Taiwan
来源：
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | 2005年 / 90卷 / 01期
关键词：
clomiphene citrate-resistant polycystic ovary syndrome; metfomin pretreatment; ovulation rate; pregnancy rate;
D O I：
10.1016/j.ijgo.2005.04.004
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To evaluate the effect of ultra-short (12 days) metformin pretreatment in clomiphene-citrate (CC) resistant polycystic ovary syndrome (PCOS). Method: Eighty women with CC-resistant PCOS were randomly allocated to metformin pretreatment or usual treatment. Forty women received 1500 mg metformin daily for 12 days, followed by clomiphene 150 mg daily for 5 days along with metformin. Forty women (control group) received the same dose of clomiphene but no metformin pretreatment. Results: In the metformin group, 17 (42.5%) women ovulated, and 6 (15%) conceived. In the control group, 5 (12.5%) women ovulated but none conceived. Compared with the control group, the metformin group had significantly higher ovulation (P=0.03) and pregnancy rates (P=0.026). Conclusion: Twelve days of metformin pretreatment improves ovulation and pregnancy rates in women with CC-resistant PCOS. (c) 2005 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：39 / 43
页数：5
相关论文
共 23 条
[1]  
[Anonymous], 1997, HUM REPROD, V12, P1191
[2]   Metformin directly inhibits androgen production in human thecal cells [J].
Attia, GR ;
Rainey, WE ;
Carr, BR .
FERTILITY AND STERILITY, 2001, 76 (03) :517-524
[3]   INSULIN STIMULATES ANDROGEN ACCUMULATION IN INCUBATIONS OF OVARIAN STROMA OBTAINED FROM WOMEN WITH HYPERANDROGENISM [J].
BARBIERI, RL ;
MAKRIS, A ;
RANDALL, RW ;
DANIELS, G ;
KISTNER, RW ;
RYAN, KJ .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1986, 62 (05) :904-910
[4]   EXCESSIVE INSULIN-RECEPTOR SERINE PHOSPHORYLATION IN CULTURED FIBROBLASTS AND IN SKELETAL-MUSCLE - A POTENTIAL MECHANISM FOR INSULIN-RESISTANCE IN THE POLYCYSTIC-OVARY-SYNDROME [J].
DUNAIF, A ;
XIA, JR ;
BOOK, CB ;
SCHENKER, E ;
TANG, ZC .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (02) :801-810
[5]  
Franks S, 1997, ANDROGEN EXCESS DISORDERS IN WOMEN, P149
[6]   MEDICAL PROGRESS - POLYCYSTIC-OVARY-SYNDROME [J].
FRANKS, S .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (13) :853-861
[7]  
HAMMOND MG, 1984, FERTIL STERIL, V42, P499
[8]   Insulin sensitizers and polycystic ovary syndrome: can a diabetes medication treat infertility? [J].
Kim, LH ;
Taylor, AE ;
Barbieri, RL .
FERTILITY AND STERILITY, 2000, 73 (06) :1097-1098
[9]   Metformin therapy improves ovulatory rates, cervical scores, and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome [J].
Kocak, M ;
Caliskan, E ;
Simsir, C ;
Haberal, A .
FERTILITY AND STERILITY, 2002, 77 (01) :101-106
[10]   Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: A prospective, controlled study in 254 affected women [J].
Legro, RS ;
Kunselman, AR ;
Dodson, WC ;
Dunaif, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (01) :165-169
123