Synthesis and biological evaluation of a new series of dihydrofolate reductase inhibitors based on the 4-(2,6-diamino-5-pyrimidinyl)alkyl-L-glutamic acid structure

被引：10

作者：

Gossett, LS ^{[1
]}

Habeck, LL ^{[1
]}

Gates, SB ^{[1
]}

Andis, SL ^{[1
]}

Worzalla, JF ^{[1
]}

Schultz, RM ^{[1
]}

Mendelsohn, LG ^{[1
]}

Kohler, W ^{[1
]}

Ratnam, M ^{[1
]}

Grindey, GB ^{[1
]}

Shih, CA ^{[1
]}

机构：

[1] MED COLL OHIO,TOLEDO,OH 43699

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 04期

关键词：

D O I：

10.1016/0960-894X(96)00053-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of dihydrofolate reductase inhibitors was uncovered during an expansion of the SAR of 5,10-dideazatetrahydrofolic acid, and their biological activity was evaluated. These new analogs do not possess an oxygen at the 4 position and contain a monocyclic pyrimidine ring.

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收藏

页码：473 / 476

页数：4

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