Lkb1 regulation of skeletal muscle development, metabolism and muscle progenitor cell homeostasis

被引：34
|
作者：
Shan, Tizhong [1 ,2 ,3 ]
Xu, Ziye [1 ,2 ,3 ]
Liu, Jiaqi [1 ,2 ,3 ]
Wu, Weiche [1 ,2 ,3 ]
Wang, Yizhen [1 ,2 ,3 ]
机构：
[1] Zhejiang Univ, Coll Anim Sci, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China
[2] Zhejiang Univ, Minist Educ, Key Lab Mol Anim Nutr, Hangzhou, Zhejiang, Peoples R China
[3] Zhejiang Univ, Zhejiang Prov Lab Feed & Anim Nutr, Hangzhou, Zhejiang, Peoples R China
来源：
JOURNAL OF CELLULAR PHYSIOLOGY | 2017年 / 232卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Lkb1; muscle development; myoblast; STK11; satellite cell; HEMATOPOIETIC STEM-CELLS; GLUCOSE-HOMEOSTASIS; AMPK; KINASE; ACTIVATION; LIVER; CONTRACTION; OXIDATION; KNOCKOUT; PROMOTES;
D O I：
10.1002/jcp.25786
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Liver kinase B1 (Lkb1), also named as Serine/Threonine protein kinase 11 (STK11), is a serine/threonine kinase that plays crucial roles in various cellular processes including cell survival, cell division, cellular polarity, cell growth, cell differentiation, and cell metabolism. In metabolic tissues, Lkb1 regulates glucose homeostasis and energy metabolism through phosphorylating and activating the AMPK subfamily proteins. In skeletal muscle, Lkb1 affects muscle development and postnatal growth, lipid and fatty acid oxidation, glucose metabolism, and insulin sensitivity. Recently, the regulatory roles of Lkb1 in regulating division, self-renew, proliferation, and differentiation of skeletal muscle progenitor cells have been reported. In this review, we discuss the roles of Lkb1 in regulating skeletal muscle progenitor cell homeostasis and skeletal muscle development and metabolism.
引用
收藏
页码：2653 / 2656
页数：4
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