Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy

被引：0
|
作者：
Kwan, Patrick [1 ]
Wong, Virginia [2 ]
Ng, Ping Wing [3 ]
Lui, Colin Hiu Tung [4 ]
Sin, Ngai Chuen [6 ]
Wong, Ka Sing [1 ]
Baum, Larry [5 ]
机构：
[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Div Neurol, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Dept Paediat & Adalescent Med, Hong Kong, Hong Kong, Peoples R China
[3] United Christian Hosp, Dept Med & Geriatr, Div Neurol, Hong Kong, Hong Kong, Peoples R China
[4] Tseung Kwan O Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
[5] Chinese Univ Hong Kong, Sch Pharm, Hong Kong, Hong Kong, Peoples R China
[6] Hosp Author Head Off, Hong Kong, Hong Kong, Peoples R China
来源：
PHARMACOGENOMICS | 2011年 / 12卷 / 03期
关键词：
ABCC2; ABCC5; ABCG2; antiepileptic drugs; drug resistance; epilepsy; pharmacogenomics; ANTIEPILEPTIC DRUGS; PROTEIN; CARBAMAZEPINE; TRANSPORT;
D O I：
10.2217/PGS.10.183
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: To determine the association between polymorphisms of the multiclrug transporter genes ABCC2, ABCC5 and ABCG2, and drug resistance in epilepsy by genotyping comprehensive sets of tagging SNPs. Materials & methods: A total of 25 tagging SNPs from ABCC2, ABCC5 and ABCG2 genes were genotyped in a total of 590 Han Chinese epilepsy patients (262 drug resistant and 328 drug responsive). Genotype and allele distributions in drug-responsive and drug-resistant patients were compared. Results: Genotype distributions of all the selected SNPs were consistent with Hardy Weinberg equilibrium. None of the polymorphisms, either genotype or allele distributions, were significantly associated with drug resistance. For each gene, no haplotypes of over 1% frequency, and that included all SNPs of the gene, were associated with drug resistance. Conclusion: This gene-wide tagging study revealed no association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy.
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收藏
页码：319 / 325
页数：7
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