No association between the DRD3 Ser9Gly polymorphism and schizophrenia

被引：19

作者：

Fathalli, Ferid ^{[1
,2
]}

Rouleau, Guy A. ^{[2
,3
]}

Xiong, Lan ^{[3
]}

Tabbane, Karim ^{[4
]}

Benkelfat, Chawki ^{[5
]}

Deguzman, Rosherrie ^{[1
]}

Zoltan, Danics ^{[6
]}

Lal, Samarthji ^{[1
,5
]}

D'cruz, Sarogini ^{[1
]}

Joober, Ridha ^{[1
,5
]}

机构：

[1] Douglas Hosp, Res Ctr, Verdun, PQ H4H 1R3, Canada

[2] Univ Montreal, Montreal, PQ, Canada

[3] Univ Montreal, Notre Dame Hosp, Res Ctr, CHUM, Montreal, PQ H2L 4M1, Canada

[4] Univ Tunis, Dept Psychiat, Tunis, Tunisia

[5] McGill Univ, Dept Psychiat, Montreal, PQ, Canada

[6] Natl Inst Psychiat, Budapest, Hungary

来源：

SCHIZOPHRENIA RESEARCH | 2008年 / 98卷 / 1-3期

基金：

加拿大健康研究院;

关键词：

schizophrenia; DRD3 (dopamine D3 receptor gene); association study; neuroleptic response;

D O I：

10.1016/j.schres.2007.07.002

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: To investigate the association between a Ser9Gly polymorphism of die dopamine D3 receptor gene (DRD3) and schizophrenia. Methods: 408 schizophrenic patients and 172 control subjects were compared with regard to their DRD3 Ser9Gly genotypic and allelic frequencies. In addition, we carried out a family-based association study including 183 pedigrees (472 subjects) using the transmission disequilibrium test (TDT). Results: No significant differences of genotype or homozygosity distribution were identified between patients and controls. When patients were stratified according to gender, response to treatment, age at onset, no significant differences were observed. Neither allele A (Set), or G (Gly) were preferentially transmitted from parents to affected offspring. Conclusion: The hypothesis that the DRD3 Ser9Gly polymorphism plays a predisposing role in schizophrenia is not supported by this study. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：98 / 104

页数：7

共 50 条

[31] Examination of new and reported data of the DRD3/Mscl polymorphism: no support for the proposed association with schizophrenia [J].

Hawi, Z ;

McCabe, U ;

Straub, RE ;

O'Neill, A ;

Kendler, KS ;

Walsh, D ;

Gill, M .

MOLECULAR PSYCHIATRY, 1998, 3 (02) :150-155

[32] Genetic association between the dopamine D3 gene polymorphism (Ser9Gly) and schizophrenia in Japanese populations: Evidence from a case-control study and meta-analysis [J].

Utsunomiya, Kensuke ;

Shinkai, Takahiro ;

De Lucac, Vincenzo ;

Hwangc, Rudi ;

Sakata, Shinichi ;

Fukunaka, Yuko ;

Chen, Hsin-I ;

Ohmori, Osamu ;

Nakamura, Jun .

NEUROSCIENCE LETTERS, 2008, 444 (02) :161-165

[33] Evidence for an association between the dopamine D3 receptor gene DRD3 and schizophrenia [J].

Ebstein, RP ;

Macciardi, F ;

HerescoLevi, U ;

Serretti, A ;

Blaine, D ;

Verga, M ;

Nebamov, L ;

Gur, E ;

Belmaker, RH ;

Avnon, M ;

Lerer, B .

HUMAN HEREDITY, 1997, 47 (01) :6-16

[34] Family based association study of DRD1, DRD2, DRD3, DRD4, DAT, COMT gene polymorphism in schizophrenia [J].

Kapelski, Pawel ;

Hauser, Joanna ;

Skibinska, Maria ;

Szczepankiewicz, Aleksandra ;

Dmitrzak-Weglarz, Monika ;

Gorzkowska, Karolina ;

Pawlak, Joanna ;

Czerski, Piotr M. .

PSYCHIATRIA POLSKA, 2010, 44 (03) :405-413

[35] Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia [J].

Novak, Gabriela ;

LeBlanc, Martha ;

Zai, Clement ;

Shaikh, Sajid ;

Renou, Julien ;

DeLuca, Vincenzo ;

Bulgin, Natalie ;

Kennedy, James L. ;

Le Foll, Bernard .

ANNALS OF HUMAN GENETICS, 2010, 74 :291-298

[36] Pharmacogenetics of tardive dyskinesia: Combined analysis of 780 patients supports association with dopamine D3 receptor gene Ser9Gly polymorphism [J].

Lerer, B ;

Segman, RH ;

Fangerau, H ;

Daly, AK ;

Basile, VS ;

Cavallaro, R ;

Aschauer, HN ;

McCreadie, RG ;

Ohlraun, S ;

Ferrier, N ;

Masellis, M ;

Verga, M ;

Scharfetter, J ;

Rietschel, M ;

Lovlie, R ;

Levy, UH ;

Meltzer, HY ;

Kennedy, JL ;

Steen, VM ;

Macciardi, F .

NEUROPSYCHOPHARMACOLOGY, 2002, 27 (01) :105-119

[37] Lack of Association Between DRD3 Gene Polymorphism and Response to Clozapine in Turkish Schizoprenia Patients [J].

Barlas, I. Omer ;

Cetin, Mesut ;

Erdal, M. Emin ;

Semiz, Umit B. ;

Basoglu, Cengiz ;

Ay, M. Ertan ;

Herken, Hasan ;

Uzun, Ozcan .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2009, 150B (01) :56-60

[38] Pharmacogenetics of Tardive Dyskinesia: Combined Analysis of 780 Patients Supports Association with Dopamine D3 Receptor Gene Ser9Gly Polymorphism [J].

Bernard Lerer ;

Ronnen H Segman ;

Heiner Fangerau ;

Ann K Daly ;

Vincenzo S Basile ;

Roberto Cavallaro ;

Harald N Aschauer ;

Robin G McCreadie ;

Stephanie Ohlraun ;

Nicol Ferrier ;

Mario Masellis ;

Massimiliano Verga ;

Joachim Scharfetter ;

Marcella Rietschel ;

Roger Lovlie ;

Uriel Heresco Levy ;

Herbert Y Meltzer ;

James L Kennedy ;

Vidar M Steen ;

Fabio Macciardi .

Neuropsychopharmacology, 2002, 27 :105-119

[39] Association study of BDNF and DRD3 genes with alcohol use disorder in Schizophrenia [J].

Zai, Clement C. ;

Manchia, Mirko ;

Zai, Gwyneth C. ;

Woo, Julia ;

Tiwari, Arun K. ;

de Luca, Vincenzo ;

Kennedy, James L. .

NEUROSCIENCE LETTERS, 2018, 671 :1-6

[40] AN ASSOCIATION STUDY BETWEEN SCHIZOPHRENIA AND THE DOPAMINE-RECEPTOR GENES DRD3 AND DRD4 USING HAPLOTYPE RELATIVE RISK [J].

MACCIARDI, F ;

VERGA, M ;

KENNEDY, JL ;

PETRONIS, A ;

BERSANI, G ;

PANCHERI, P ;

SMERALDI, E .

HUMAN HEREDITY, 1994, 44 (06) :328-336

← 1 2 3 4 5 →